Retrieving functional pathways of biomolecules from single-particle snapshots

There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the functional pathways traversed on experimentally derived en...

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Autores principales:	Ali Dashti, Ghoncheh Mashayekhi, Mrinal Shekhar, Danya Ben Hail, Salah Salah, Peter Schwander, Amedee des Georges, Abhishek Singharoy, Joachim Frank, Abbas Ourmazd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec2
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spelling	oai:doaj.org-article:a9730a6e4420466a99ccf8fd2dbeaec22021-12-02T18:33:51ZRetrieving functional pathways of biomolecules from single-particle snapshots10.1038/s41467-020-18403-x2041-1723https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18403-xhttps://doaj.org/toc/2041-1723There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the functional pathways traversed on experimentally derived energy landscapes using the ryanodine receptor type 1 as an example.Ali DashtiGhoncheh MashayekhiMrinal ShekharDanya Ben HailSalah SalahPeter SchwanderAmedee des GeorgesAbhishek SingharoyJoachim FrankAbbas OurmazdNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ali Dashti Ghoncheh Mashayekhi Mrinal Shekhar Danya Ben Hail Salah Salah Peter Schwander Amedee des Georges Abhishek Singharoy Joachim Frank Abbas Ourmazd Retrieving functional pathways of biomolecules from single-particle snapshots
description	There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the functional pathways traversed on experimentally derived energy landscapes using the ryanodine receptor type 1 as an example.
format	article
author	Ali Dashti Ghoncheh Mashayekhi Mrinal Shekhar Danya Ben Hail Salah Salah Peter Schwander Amedee des Georges Abhishek Singharoy Joachim Frank Abbas Ourmazd
author_facet	Ali Dashti Ghoncheh Mashayekhi Mrinal Shekhar Danya Ben Hail Salah Salah Peter Schwander Amedee des Georges Abhishek Singharoy Joachim Frank Abbas Ourmazd
author_sort	Ali Dashti
title	Retrieving functional pathways of biomolecules from single-particle snapshots
title_short	Retrieving functional pathways of biomolecules from single-particle snapshots
title_full	Retrieving functional pathways of biomolecules from single-particle snapshots
title_fullStr	Retrieving functional pathways of biomolecules from single-particle snapshots
title_full_unstemmed	Retrieving functional pathways of biomolecules from single-particle snapshots
title_sort	retrieving functional pathways of biomolecules from single-particle snapshots
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec2
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Retrieving functional pathways of biomolecules from single-particle snapshots

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