Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study

Abstract We evaluated the risk of developing diabetes in Chinese individuals with normal weight obesity (NWO). This 9-year population-based cohort study was based on the China National Diabetes and Metabolic Disorders Survey. A total of 1128 subjects without diabetes were included. Body fat percenta...

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Autores principales:	Shaoyong Xu, Jie Ming, Aihua Jia, Xinwen Yu, Jing Cai, Ce Jing, Chun Liu, Qiuhe Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a976dd95aca447918388b5af2f9ef592
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spelling	oai:doaj.org-article:a976dd95aca447918388b5af2f9ef5922021-12-02T11:39:43ZNormal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study10.1038/s41598-021-85573-z2045-2322https://doaj.org/article/a976dd95aca447918388b5af2f9ef5922021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85573-zhttps://doaj.org/toc/2045-2322Abstract We evaluated the risk of developing diabetes in Chinese individuals with normal weight obesity (NWO). This 9-year population-based cohort study was based on the China National Diabetes and Metabolic Disorders Survey. A total of 1128 subjects without diabetes were included. Body fat percentage (BF%) was assessed by electrical bioimpedance. NWO was defined as subjects with a normal BMI (< 24 kg/m2) and an excess BF% (≥ 24% in men; ≥ 33% in women). Of 1128 individuals, 528 individuals were normal weight non-obese (NWNO), 118 (10.5%) were normal weight obese (NWO), 63 were overweight non-obese (OWNO), and 419 were overweight obese (OWO). During a follow-up of 9.0 years (interquartile range: 8.9–9.3), 113 (10.0%) individuals developed diabetes. The incidence rates of diabetes in NWNO, NWO, OWNO and OWO people were 5.69 (27 cases), 11.30 (12 cases), 3.53 (2 cases) and 19.09 (72 cases) per 1000 person-years, respectively. Cox regression analyses indicated multivariate-adjusted hazard ratios of diabetes in NWO, OWNO and OWO people were 2.110 (95% CI 1.026–4.337, p = 0.025), 0.441 (95% CI 0.101–1.928, p = 0.232) and 3.465 (95% CI 2.163–5.551, p < 0.001), respectively, relative to NWNO people. Chinese people with NWO are at increased risk of developing diabetes. We strongly suggest the incorporation of BF% measurement into the regular physical examination in Chinese medical practice.Shaoyong XuJie MingAihua JiaXinwen YuJing CaiCe JingChun LiuQiuhe JiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shaoyong Xu Jie Ming Aihua Jia Xinwen Yu Jing Cai Ce Jing Chun Liu Qiuhe Ji Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
description	Abstract We evaluated the risk of developing diabetes in Chinese individuals with normal weight obesity (NWO). This 9-year population-based cohort study was based on the China National Diabetes and Metabolic Disorders Survey. A total of 1128 subjects without diabetes were included. Body fat percentage (BF%) was assessed by electrical bioimpedance. NWO was defined as subjects with a normal BMI (< 24 kg/m2) and an excess BF% (≥ 24% in men; ≥ 33% in women). Of 1128 individuals, 528 individuals were normal weight non-obese (NWNO), 118 (10.5%) were normal weight obese (NWO), 63 were overweight non-obese (OWNO), and 419 were overweight obese (OWO). During a follow-up of 9.0 years (interquartile range: 8.9–9.3), 113 (10.0%) individuals developed diabetes. The incidence rates of diabetes in NWNO, NWO, OWNO and OWO people were 5.69 (27 cases), 11.30 (12 cases), 3.53 (2 cases) and 19.09 (72 cases) per 1000 person-years, respectively. Cox regression analyses indicated multivariate-adjusted hazard ratios of diabetes in NWO, OWNO and OWO people were 2.110 (95% CI 1.026–4.337, p = 0.025), 0.441 (95% CI 0.101–1.928, p = 0.232) and 3.465 (95% CI 2.163–5.551, p < 0.001), respectively, relative to NWNO people. Chinese people with NWO are at increased risk of developing diabetes. We strongly suggest the incorporation of BF% measurement into the regular physical examination in Chinese medical practice.
format	article
author	Shaoyong Xu Jie Ming Aihua Jia Xinwen Yu Jing Cai Ce Jing Chun Liu Qiuhe Ji
author_facet	Shaoyong Xu Jie Ming Aihua Jia Xinwen Yu Jing Cai Ce Jing Chun Liu Qiuhe Ji
author_sort	Shaoyong Xu
title	Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
title_short	Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
title_full	Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
title_fullStr	Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
title_full_unstemmed	Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study
title_sort	normal weight obesity and the risk of diabetes in chinese people: a 9-year population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a976dd95aca447918388b5af2f9ef592
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Normal weight obesity and the risk of diabetes in Chinese people: a 9-year population-based cohort study

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