The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase

One goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryota Akiyama, Bunta Watanabe, Masaru Nakayasu, Hyoung Jae Lee, Junpei Kato, Naoyuki Umemoto, Toshiya Muranaka, Kazuki Saito, Yukihiro Sugimoto, Masaharu Mizutani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a979c63a4d054a6391ecae62f87f29bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a979c63a4d054a6391ecae62f87f29bb
record_format	dspace
spelling	oai:doaj.org-article:a979c63a4d054a6391ecae62f87f29bb2021-12-02T13:34:49ZThe biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase10.1038/s41467-021-21546-02041-1723https://doaj.org/article/a979c63a4d054a6391ecae62f87f29bb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21546-0https://doaj.org/toc/2041-1723One goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other solanaceous plants.Ryota AkiyamaBunta WatanabeMasaru NakayasuHyoung Jae LeeJunpei KatoNaoyuki UmemotoToshiya MuranakaKazuki SaitoYukihiro SugimotoMasaharu MizutaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
description	One goal of potato breeding is to reduce the accumulation of toxic solanidane glycoalkaloids. Here the authors show that potato DPS, a 2-oxoglutarate dependent dioxygenase, catalyzes ring rearrangement of a biosynthetic precursor to differentiate solanidanes from spirosolanes that are found in other solanaceous plants.
format	article
author	Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani
author_facet	Ryota Akiyama Bunta Watanabe Masaru Nakayasu Hyoung Jae Lee Junpei Kato Naoyuki Umemoto Toshiya Muranaka Kazuki Saito Yukihiro Sugimoto Masaharu Mizutani
author_sort	Ryota Akiyama
title	The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
title_short	The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
title_full	The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
title_fullStr	The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
title_full_unstemmed	The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
title_sort	biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a979c63a4d054a6391ecae62f87f29bb
work_keys_str_mv	AT ryotaakiyama thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT buntawatanabe thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT masarunakayasu thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT hyoungjaelee thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT junpeikato thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT naoyukiumemoto thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT toshiyamuranaka thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT kazukisaito thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT yukihirosugimoto thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT masaharumizutani thebiosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT ryotaakiyama biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT buntawatanabe biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT masarunakayasu biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT hyoungjaelee biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT junpeikato biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT naoyukiumemoto biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT toshiyamuranaka biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT kazukisaito biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT yukihirosugimoto biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase AT masaharumizutani biosyntheticpathwayofpotatosolanidanesdivergedfromthatofspirosolanesduetoevolutionofadioxygenase
_version_	1718392754969509888

The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase

Ejemplares similares