A validation study of the Chinese-Cantonese Addenbrooke’s Cognitive Examination Revised (C-ACER)

LL Wong,1 CC Chan,2 JL Leung,1 CY Yung,2 KK Wu,3 SYY Cheung,3 CLM Lam4 1Department of Psychiatry, 2Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong; 3Clinical Psychology Services, Kwai Chung Hospital, Kwai Chung, New Territories, Hong Kong; 4Hong Kong F...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wong LL, Chan CC, Leung JL, Yung CY, Wu KK, Cheung SYY, Lam CLM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://doaj.org/article/a979f6a70ab64e05bce0491128f0ee16
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a979f6a70ab64e05bce0491128f0ee16
record_format dspace
spelling oai:doaj.org-article:a979f6a70ab64e05bce0491128f0ee162021-12-02T08:25:15ZA validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)1176-63281178-2021https://doaj.org/article/a979f6a70ab64e05bce0491128f0ee162013-06-01T00:00:00Zhttp://www.dovepress.com/a-validation-study-of-the-chinese-cantonese-addenbrookersquos-cognitiv-a13280https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021LL Wong,1 CC Chan,2 JL Leung,1 CY Yung,2 KK Wu,3 SYY Cheung,3 CLM Lam4 1Department of Psychiatry, 2Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong; 3Clinical Psychology Services, Kwai Chung Hospital, Kwai Chung, New Territories, Hong Kong; 4Hong Kong Federation of Youth Groups, Department of Clinical Psychology, Tseung Kwan O Hospital, Tseung Kwan O, New Territories, Hong Kong Background: There is no valid instrument for multidomain cognitive assessment to aid the detection of mild cognitive impairment (MCI) and mild dementia in Hong Kong. This study aimed to validate the Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER) in the identification of MCI and dementia. Methods: 147 participants (Dementia, n = 54; MCI, n = 50; controls, n = 43) aged 60 or above were assessed by a psychiatrist using C-ACER. The C-ACER scores were validated against the expert diagnosis according to DSM-IV criteria for dementia and Petersen criteria for MCI. Statistical analysis was performed using the receiver operating characteristic method and regression analyses. Results: The optimal cut-off score for the C-ACER to differentiate MCI from normal controls was 79/80, giving the sensitivity of 0.74, specificity of 0.84 and area under curve (AUC) of 0.84. At the optimal cut-off of 73/74, C-ACER had satisfactory sensitivity (0.93), specificity (0.95) and AUC (0.98) to identify dementia from controls. Performance of C-ACER, as reflected by AUC, was not affected after adjustment of the effect of education level. Total C-ACER scores were significantly correlated with scores of global deterioration scale (Spearman&rsquo;s rho = &minus;0.73, P < 0.01). Conclusion: C-ACER is a sensitive and specific bedside test to assess a broad spectrum of cognitive abilities, and to detect MCI and dementia of different severity. It can be used and interpreted with ease, without the need to adjust for education level in persons aged 60 or above. Keywords: dementia, mild cognitive impairment, multidomain, bedside, assessment, Hong KongWong LLChan CCLeung JLYung CYWu KKCheung SYYLam CLMDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 731-737 (2013)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Wong LL
Chan CC
Leung JL
Yung CY
Wu KK
Cheung SYY
Lam CLM
A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
description LL Wong,1 CC Chan,2 JL Leung,1 CY Yung,2 KK Wu,3 SYY Cheung,3 CLM Lam4 1Department of Psychiatry, 2Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong; 3Clinical Psychology Services, Kwai Chung Hospital, Kwai Chung, New Territories, Hong Kong; 4Hong Kong Federation of Youth Groups, Department of Clinical Psychology, Tseung Kwan O Hospital, Tseung Kwan O, New Territories, Hong Kong Background: There is no valid instrument for multidomain cognitive assessment to aid the detection of mild cognitive impairment (MCI) and mild dementia in Hong Kong. This study aimed to validate the Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER) in the identification of MCI and dementia. Methods: 147 participants (Dementia, n = 54; MCI, n = 50; controls, n = 43) aged 60 or above were assessed by a psychiatrist using C-ACER. The C-ACER scores were validated against the expert diagnosis according to DSM-IV criteria for dementia and Petersen criteria for MCI. Statistical analysis was performed using the receiver operating characteristic method and regression analyses. Results: The optimal cut-off score for the C-ACER to differentiate MCI from normal controls was 79/80, giving the sensitivity of 0.74, specificity of 0.84 and area under curve (AUC) of 0.84. At the optimal cut-off of 73/74, C-ACER had satisfactory sensitivity (0.93), specificity (0.95) and AUC (0.98) to identify dementia from controls. Performance of C-ACER, as reflected by AUC, was not affected after adjustment of the effect of education level. Total C-ACER scores were significantly correlated with scores of global deterioration scale (Spearman&rsquo;s rho = &minus;0.73, P < 0.01). Conclusion: C-ACER is a sensitive and specific bedside test to assess a broad spectrum of cognitive abilities, and to detect MCI and dementia of different severity. It can be used and interpreted with ease, without the need to adjust for education level in persons aged 60 or above. Keywords: dementia, mild cognitive impairment, multidomain, bedside, assessment, Hong Kong
format article
author Wong LL
Chan CC
Leung JL
Yung CY
Wu KK
Cheung SYY
Lam CLM
author_facet Wong LL
Chan CC
Leung JL
Yung CY
Wu KK
Cheung SYY
Lam CLM
author_sort Wong LL
title A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
title_short A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
title_full A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
title_fullStr A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
title_full_unstemmed A validation study of the Chinese-Cantonese Addenbrooke&rsquo;s Cognitive Examination Revised (C-ACER)
title_sort validation study of the chinese-cantonese addenbrooke&rsquo;s cognitive examination revised (c-acer)
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/a979f6a70ab64e05bce0491128f0ee16
work_keys_str_mv AT wongll avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT chancc avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT leungjl avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT yungcy avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT wukk avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT cheungsyy avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT lamclm avalidationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT wongll validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT chancc validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT leungjl validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT yungcy validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT wukk validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT cheungsyy validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
AT lamclm validationstudyofthechinesecantoneseaddenbrookersquoscognitiveexaminationrevisedcacer
_version_ 1718398503038746624