Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartment...

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Autores principales:	Emily Dosmar, Gabrielle Vuotto, Xingqi Su, Emily Roberts, Abigail Lannoy, Garet J. Bailey, William F. Mieler, Jennifer J. Kang-Mieler
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	targeted drug delivery ocular drug delivery compartmental modeling pharmacokinetic modeling COMSOL 3D modeling hydrogels Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/a97dccf7d2ef4faf9cfcbbb4ff1e9c77
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spelling	oai:doaj.org-article:a97dccf7d2ef4faf9cfcbbb4ff1e9c772021-11-25T18:41:15ZCompartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System10.3390/pharmaceutics131118621999-4923https://doaj.org/article/a97dccf7d2ef4faf9cfcbbb4ff1e9c772021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1862https://doaj.org/toc/1999-4923The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.Emily DosmarGabrielle VuottoXingqi SuEmily RobertsAbigail LannoyGaret J. BaileyWilliam F. MielerJennifer J. Kang-MielerMDPI AGarticletargeted drug deliveryocular drug deliverycompartmental modelingpharmacokinetic modelingCOMSOL 3D modelinghydrogelsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1862, p 1862 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	targeted drug delivery ocular drug delivery compartmental modeling pharmacokinetic modeling COMSOL 3D modeling hydrogels Pharmacy and materia medica RS1-441
spellingShingle	targeted drug delivery ocular drug delivery compartmental modeling pharmacokinetic modeling COMSOL 3D modeling hydrogels Pharmacy and materia medica RS1-441 Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
description	The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.
format	article
author	Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler
author_facet	Emily Dosmar Gabrielle Vuotto Xingqi Su Emily Roberts Abigail Lannoy Garet J. Bailey William F. Mieler Jennifer J. Kang-Mieler
author_sort	Emily Dosmar
title	Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
title_short	Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
title_full	Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
title_fullStr	Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
title_full_unstemmed	Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System
title_sort	compartmental and comsol multiphysics 3d modeling of drug diffusion to the vitreous following the administration of a sustained-release drug delivery system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a97dccf7d2ef4faf9cfcbbb4ff1e9c77
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Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

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