Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques

Feng-Li Deng,1–4,* Jun-Xi Pan,2,3,5,* Peng Zheng,2,3,6 Jin-Jun Xia,2,3 Bang-Min Yin,1–3 Wei-Wei Liang,1–3 Yi-Fan Li,2,3,6 Jing Wu,2,3 Fan Xu,2,3 Qing-Yuan Wu,2,3,7 Chao-Hua Qu,2,3 Wei Li,2,3 Hai-Yang Wang,2,3 Peng Xie1–31Dep...

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Autores principales:	Deng F, Pan J, Zheng P, Xia J, Yin B, Liang W, Li Y, Wu J, Xu F, Wu Q, Qu C, Li W, Wang H, Xie P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	naturally-occurring depressive depression non-human primate metabonomics cerebrospinal fluid short-chain fatty acid Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a980dc641a2045708736ecd874f2c758
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spelling	oai:doaj.org-article:a980dc641a2045708736ecd874f2c7582021-12-02T08:49:16ZMetabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques1178-2021https://doaj.org/article/a980dc641a2045708736ecd874f2c7582019-05-01T00:00:00Zhttps://www.dovepress.com/metabonomics-reveals-peripheral-and-central-short-chain-fatty-acid-and-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feng-Li Deng,1–4,* Jun-Xi Pan,2,3,5,* Peng Zheng,2,3,6 Jin-Jun Xia,2,3 Bang-Min Yin,1–3 Wei-Wei Liang,1–3 Yi-Fan Li,2,3,6 Jing Wu,2,3 Fan Xu,2,3 Qing-Yuan Wu,2,3,7 Chao-Hua Qu,2,3 Wei Li,2,3 Hai-Yang Wang,2,3 Peng Xie1–31Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China; 2Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China; 3Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 4School of Public Health and Management, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 5The First Affiliated Hospital of Kunming Medical University, Kunming 650032, People’s Republic of China; 6Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China; 7Department of Neurology, Three Gorges Central Hospital, Chongqing Medical University, Chongqing 400016, People’s Republic of China *These authors contributed equally to this work Purpose: Depression is a complex psychiatric disorder. Various depressive rodent models are usually constructed based on different pathogenesis hypotheses.Materials and methods: Herein, using our previously established naturally occurring depressive (NOD) model in a non-human primate (cynomolgus monkey, Macaca fascularis), we performed metabolomics analysis of cerebrospinal fluid (CSF) from NOD female macaques (N=10) and age- and gender-matched healthy controls (HCs) (N=12). Multivariate statistical analysis was used to identify the differentially expressed metabolites between the two groups. Ingenuity Pathways Analysis and MetaboAnalyst were applied for predicted pathways and biological functions analysis.Results: Totally, 37 metabolites responsible for discriminating the two groups were identified. The NOD macaques were mainly characterized by perturbations of fatty acid biosynthesis, ABC transport system, and amino acid metabolism (eg, aspartate, glycine, serine, and threonine metabolism). Interestingly, we found that eight altered CSF metabolites belonging to short-chain fatty acids and amino acids were also observed in the serum of NOD macaques (N=13 per group).Conclusion: Our findings suggest that peripheral and central short-chain fatty acids and amino acids are implicated in the onset of depression.Keywords: naturally occurring depressive, depression, non-human primate, metabonomics, cerebrospinal fluid, short-chain fatty acidDeng FPan JZheng PXia JYin BLiang WLi YWu JXu FWu QQu CLi WWang HXie PDove Medical Pressarticlenaturally-occurring depressivedepressionnon-human primatemetabonomicscerebrospinal fluidshort-chain fatty acidNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1077-1088 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	naturally-occurring depressive depression non-human primate metabonomics cerebrospinal fluid short-chain fatty acid Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	naturally-occurring depressive depression non-human primate metabonomics cerebrospinal fluid short-chain fatty acid Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Deng F Pan J Zheng P Xia J Yin B Liang W Li Y Wu J Xu F Wu Q Qu C Li W Wang H Xie P Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
description	Feng-Li Deng,1–4,* Jun-Xi Pan,2,3,5,* Peng Zheng,2,3,6 Jin-Jun Xia,2,3 Bang-Min Yin,1–3 Wei-Wei Liang,1–3 Yi-Fan Li,2,3,6 Jing Wu,2,3 Fan Xu,2,3 Qing-Yuan Wu,2,3,7 Chao-Hua Qu,2,3 Wei Li,2,3 Hai-Yang Wang,2,3 Peng Xie1–31Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, People’s Republic of China; 2Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China; 3Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 4School of Public Health and Management, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 5The First Affiliated Hospital of Kunming Medical University, Kunming 650032, People’s Republic of China; 6Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China; 7Department of Neurology, Three Gorges Central Hospital, Chongqing Medical University, Chongqing 400016, People’s Republic of China *These authors contributed equally to this work Purpose: Depression is a complex psychiatric disorder. Various depressive rodent models are usually constructed based on different pathogenesis hypotheses.Materials and methods: Herein, using our previously established naturally occurring depressive (NOD) model in a non-human primate (cynomolgus monkey, Macaca fascularis), we performed metabolomics analysis of cerebrospinal fluid (CSF) from NOD female macaques (N=10) and age- and gender-matched healthy controls (HCs) (N=12). Multivariate statistical analysis was used to identify the differentially expressed metabolites between the two groups. Ingenuity Pathways Analysis and MetaboAnalyst were applied for predicted pathways and biological functions analysis.Results: Totally, 37 metabolites responsible for discriminating the two groups were identified. The NOD macaques were mainly characterized by perturbations of fatty acid biosynthesis, ABC transport system, and amino acid metabolism (eg, aspartate, glycine, serine, and threonine metabolism). Interestingly, we found that eight altered CSF metabolites belonging to short-chain fatty acids and amino acids were also observed in the serum of NOD macaques (N=13 per group).Conclusion: Our findings suggest that peripheral and central short-chain fatty acids and amino acids are implicated in the onset of depression.Keywords: naturally occurring depressive, depression, non-human primate, metabonomics, cerebrospinal fluid, short-chain fatty acid
format	article
author	Deng F Pan J Zheng P Xia J Yin B Liang W Li Y Wu J Xu F Wu Q Qu C Li W Wang H Xie P
author_facet	Deng F Pan J Zheng P Xia J Yin B Liang W Li Y Wu J Xu F Wu Q Qu C Li W Wang H Xie P
author_sort	Deng F
title	Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
title_short	Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
title_full	Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
title_fullStr	Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
title_full_unstemmed	Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
title_sort	metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a980dc641a2045708736ecd874f2c758
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Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques

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