ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT

This study evaluates the effects on arterial pressure and pithed heart frequency rate induced by the ethanolic extract of Solanum tuberosum, a species used in Colombian folk medicine for the treatment or arterial hypertension, compared with a-solanine and a-chaconine -the main glycoa...

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Autores principales:	Juan M. GÓMEZ, Mario F. GUERRERO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	a-solanine a-chaconine chlorogenic acid Solanum tuberosum nitric oxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/a983628c257447439126083d41cc9c69
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spelling	oai:doaj.org-article:a983628c257447439126083d41cc9c692021-11-19T04:14:55ZASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT0121-40042145-2660https://doaj.org/article/a983628c257447439126083d41cc9c692009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/2802https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 This study evaluates the effects on arterial pressure and pithed heart frequency rate induced by the ethanolic extract of Solanum tuberosum, a species used in Colombian folk medicine for the treatment or arterial hypertension, compared with a-solanine and a-chaconine -the main glycoalcaloids of S. tuberosum- the mixture of both glycoalcaloids (50:50) and chlorogenic acid, the main polyphenolic compound present in this species. The effect of the extract in presence of noradrenalin (0.25 - 2.5 μg/Kg, IV) and L-NAME (10 mg/Kg, IV), inhibitor of nitric oxide sintase, is also studied. These results show that whereas the etanolic extract decreases the blood pressure in a dose - response manner (1 μg/Kg - 10 mg/Kg, IV) and reduces the increase of this variable induced by noradrenalin. It has been not demonstrated that the glycoalcaloid compounds, the alkaloidal mixture (50:50), or the chlorogenic acid were able to reduce the arterial pressure. The effect of the extract is reverted partially in the presence of L-NAME. In conclusion, the etanolic extract of S. tuberosum exerts hypotensive effects related partially with the nitric oxide production, non-attributable to the presence of a-solanine, a-chaconine or chlorogenic acid. Juan M. GÓMEZMario F. GUERREROUniversidad de Antioquiaarticlea-solaninea-chaconinechlorogenic acidSolanum tuberosumnitric oxide.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	a-solanine a-chaconine chlorogenic acid Solanum tuberosum nitric oxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	a-solanine a-chaconine chlorogenic acid Solanum tuberosum nitric oxide. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Juan M. GÓMEZ Mario F. GUERRERO ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
description	This study evaluates the effects on arterial pressure and pithed heart frequency rate induced by the ethanolic extract of Solanum tuberosum, a species used in Colombian folk medicine for the treatment or arterial hypertension, compared with a-solanine and a-chaconine -the main glycoalcaloids of S. tuberosum- the mixture of both glycoalcaloids (50:50) and chlorogenic acid, the main polyphenolic compound present in this species. The effect of the extract in presence of noradrenalin (0.25 - 2.5 μg/Kg, IV) and L-NAME (10 mg/Kg, IV), inhibitor of nitric oxide sintase, is also studied. These results show that whereas the etanolic extract decreases the blood pressure in a dose - response manner (1 μg/Kg - 10 mg/Kg, IV) and reduces the increase of this variable induced by noradrenalin. It has been not demonstrated that the glycoalcaloid compounds, the alkaloidal mixture (50:50), or the chlorogenic acid were able to reduce the arterial pressure. The effect of the extract is reverted partially in the presence of L-NAME. In conclusion, the etanolic extract of S. tuberosum exerts hypotensive effects related partially with the nitric oxide production, non-attributable to the presence of a-solanine, a-chaconine or chlorogenic acid.
format	article
author	Juan M. GÓMEZ Mario F. GUERRERO
author_facet	Juan M. GÓMEZ Mario F. GUERRERO
author_sort	Juan M. GÓMEZ
title	ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
title_short	ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
title_full	ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
title_fullStr	ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
title_full_unstemmed	ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT
title_sort	assessment of the cardiovascular effects of the extract and compounds from <i>solanum tuberosum</i> in the pithed rat
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/a983628c257447439126083d41cc9c69
work_keys_str_mv	AT juanmgomez assessmentofthecardiovasculareffectsoftheextractandcompoundsfromisolanumtuberosumiinthepithedrat AT mariofguerrero assessmentofthecardiovasculareffectsoftheextractandcompoundsfromisolanumtuberosumiinthepithedrat
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ASSESSMENT OF THE CARDIOVASCULAR EFFECTS OF THE EXTRACT AND COMPOUNDS FROM <I>Solanum tuberosum</I> IN THE PITHED RAT

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