Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer

Abstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit fro...

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Autores principales:	Matias Blomqvist, Ilmari Koskinen, Eliisa Löyttyniemi, Tuomas Mirtti, Peter J. Boström, Pekka Taimen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a983ad99b731480d86231b5faa38df2f
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spelling	oai:doaj.org-article:a983ad99b731480d86231b5faa38df2f2021-12-02T16:10:38ZPrognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer10.1038/s41598-021-93245-12045-2322https://doaj.org/article/a983ad99b731480d86231b5faa38df2f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93245-1https://doaj.org/toc/2045-2322Abstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit from NAC. Presence of cancer stem cells (CSC) has been associated with poor outcome and resistance to chemotherapy in various cancers. Here we studied the expression of stem cell markers ALDH1, SOX2 and SSEA-4 with immunohistochemistry in tissue microarray material consisting of 195 BC patients treated with RC and 74 patients treated with TUR-BT followed by NAC and RC. Post-operative follow-up data of up to 22 years was used. Negative to weak cytoplasmic SOX2 staining was associated with lymphovascular invasion and non-organ confined disease. It was also associated with shortened cancer-specific survival, but the finding was not statistically significant. Contrary to previous reports, none of the other tested biomarkers were associated with cancer-specific mortality or clinicopathological characteristics. Neither were they associated with response to NAC. Despite the promising results of previously published studies, our results suggest that CSC markers ALDH1, SOX2 and SSEA-4 have little if any prognostic or predictive value in BC treated with RC.Matias BlomqvistIlmari KoskinenEliisa LöyttyniemiTuomas MirttiPeter J. BoströmPekka TaimenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
description	Abstract Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy (NAC) prior to RC improves outcome of some patients but currently there are no valid biomarkers to identify patients who benefit from NAC. Presence of cancer stem cells (CSC) has been associated with poor outcome and resistance to chemotherapy in various cancers. Here we studied the expression of stem cell markers ALDH1, SOX2 and SSEA-4 with immunohistochemistry in tissue microarray material consisting of 195 BC patients treated with RC and 74 patients treated with TUR-BT followed by NAC and RC. Post-operative follow-up data of up to 22 years was used. Negative to weak cytoplasmic SOX2 staining was associated with lymphovascular invasion and non-organ confined disease. It was also associated with shortened cancer-specific survival, but the finding was not statistically significant. Contrary to previous reports, none of the other tested biomarkers were associated with cancer-specific mortality or clinicopathological characteristics. Neither were they associated with response to NAC. Despite the promising results of previously published studies, our results suggest that CSC markers ALDH1, SOX2 and SSEA-4 have little if any prognostic or predictive value in BC treated with RC.
format	article
author	Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen
author_facet	Matias Blomqvist Ilmari Koskinen Eliisa Löyttyniemi Tuomas Mirtti Peter J. Boström Pekka Taimen
author_sort	Matias Blomqvist
title	Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
title_short	Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
title_full	Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
title_fullStr	Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
title_full_unstemmed	Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer
title_sort	prognostic and predictive value of aldh1, sox2 and ssea-4 in bladder cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a983ad99b731480d86231b5faa38df2f
work_keys_str_mv	AT matiasblomqvist prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT ilmarikoskinen prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT eliisaloyttyniemi prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT tuomasmirtti prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT peterjbostrom prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer AT pekkataimen prognosticandpredictivevalueofaldh1sox2andssea4inbladdercancer
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Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer

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