Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?
Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a9848339c5df4201aff9b1a92b7f8bfd2021-11-04T14:00:40ZCase Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?1664-322410.3389/fimmu.2021.745146https://doaj.org/article/a9848339c5df4201aff9b1a92b7f8bfd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.745146/fullhttps://doaj.org/toc/1664-3224Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.Patricia Martin-RomanoJulien AdamJean-Yves ScoazecSébastien GouyAntonin LevyCapucine BaldiniStéphane ChampiatJean-Charles SoriaJean-Charles SoriaJean-Charles SoriaChristophe MassardAurélien MarabelleEric DeutschEric DeutschEric DeutschAntoine HollebecqueFrontiers Media S.A.articleimmunotherapyradiation therapytumor responseimmune microenvironmentanal squamous cell carcinomaImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
immunotherapy radiation therapy tumor response immune microenvironment anal squamous cell carcinoma Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
immunotherapy radiation therapy tumor response immune microenvironment anal squamous cell carcinoma Immunologic diseases. Allergy RC581-607 Patricia Martin-Romano Julien Adam Jean-Yves Scoazec Sébastien Gouy Antonin Levy Capucine Baldini Stéphane Champiat Jean-Charles Soria Jean-Charles Soria Jean-Charles Soria Christophe Massard Aurélien Marabelle Eric Deutsch Eric Deutsch Eric Deutsch Antoine Hollebecque Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| description |
Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response. |
| format |
article |
| author |
Patricia Martin-Romano Julien Adam Jean-Yves Scoazec Sébastien Gouy Antonin Levy Capucine Baldini Stéphane Champiat Jean-Charles Soria Jean-Charles Soria Jean-Charles Soria Christophe Massard Aurélien Marabelle Eric Deutsch Eric Deutsch Eric Deutsch Antoine Hollebecque |
| author_facet |
Patricia Martin-Romano Julien Adam Jean-Yves Scoazec Sébastien Gouy Antonin Levy Capucine Baldini Stéphane Champiat Jean-Charles Soria Jean-Charles Soria Jean-Charles Soria Christophe Massard Aurélien Marabelle Eric Deutsch Eric Deutsch Eric Deutsch Antoine Hollebecque |
| author_sort |
Patricia Martin-Romano |
| title |
Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| title_short |
Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| title_full |
Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| title_fullStr |
Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| title_full_unstemmed |
Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? |
| title_sort |
case report: response to immunotherapy, can radiotherapy be a troublemaker? |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a9848339c5df4201aff9b1a92b7f8bfd |
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