GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION

The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, thi...

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Autores principales:	V. V. Sutyagin, T. V. Meka-Mechenko, G. G. Kovaleva, A. T. Berdibekov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	great gerbil yersinia pestis infectious sensitivity Science Q
Acceso en línea:	https://doaj.org/article/a984afd7d6434c51bfc6b49d639cd1a7
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spelling	oai:doaj.org-article:a984afd7d6434c51bfc6b49d639cd1a72021-11-23T06:14:41ZGENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION2541-94202587-959610.29413/ABS.2018-3.4.4https://doaj.org/article/a984afd7d6434c51bfc6b49d639cd1a72018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/643https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, this feature can be described using a monogenic model of inheritance with one gene. In addition to the genetic component, other modifying factors of biotic and abiotic nature may influence the sensitivity of a great gerbil to infection.The aim of the work was to evaluate the role of genetic and modifying factors in the variation of the sensitivity of the great gerbil to the causative agent of plague. For this, a one-factor analysis of variance was used. The strength of the effect of the intensity of plague epizootics on sensitivity was calculated by the method of Plokhinsky. As a result, it was found that approximately 87 ± 3.9 % of the total variation of the sensitivity sign is due to its genetic component and about 13 % to the share of other factors affecting the characteristic (modifying factors). The conclusion is made that while in studies on the sensitivity of rodents the effect on regulation of the immune response (specific for specific antigens) has not been demonstrated, it is necessary to talk about the general infectious sensitivity of rodents to infections, for example, the causative agent of plague.V. V. SutyaginT. V. Meka-MechenkoG. G. KovalevaA. T. BerdibekovScientific Сentre for Family Health and Human Reproduction Problemsarticlegreat gerbilyersinia pestisinfectious sensitivityScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 27-30 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	great gerbil yersinia pestis infectious sensitivity Science Q
spellingShingle	great gerbil yersinia pestis infectious sensitivity Science Q V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
description	The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information on the involved genes and their effect on this feature in the literature. Although the sensitivity of gerbils to plague microbe may depend on many genes, this feature can be described using a monogenic model of inheritance with one gene. In addition to the genetic component, other modifying factors of biotic and abiotic nature may influence the sensitivity of a great gerbil to infection.The aim of the work was to evaluate the role of genetic and modifying factors in the variation of the sensitivity of the great gerbil to the causative agent of plague. For this, a one-factor analysis of variance was used. The strength of the effect of the intensity of plague epizootics on sensitivity was calculated by the method of Plokhinsky. As a result, it was found that approximately 87 ± 3.9 % of the total variation of the sensitivity sign is due to its genetic component and about 13 % to the share of other factors affecting the characteristic (modifying factors). The conclusion is made that while in studies on the sensitivity of rodents the effect on regulation of the immune response (specific for specific antigens) has not been demonstrated, it is necessary to talk about the general infectious sensitivity of rodents to infections, for example, the causative agent of plague.
format	article
author	V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov
author_facet	V. V. Sutyagin T. V. Meka-Mechenko G. G. Kovaleva A. T. Berdibekov
author_sort	V. V. Sutyagin
title	GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
title_short	GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
title_full	GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
title_fullStr	GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
title_full_unstemmed	GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION
title_sort	genetic component of great gerbil’s susceptibility to plague infection
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/a984afd7d6434c51bfc6b49d639cd1a7
work_keys_str_mv	AT vvsutyagin geneticcomponentofgreatgerbilssusceptibilitytoplagueinfection AT tvmekamechenko geneticcomponentofgreatgerbilssusceptibilitytoplagueinfection AT ggkovaleva geneticcomponentofgreatgerbilssusceptibilitytoplagueinfection AT atberdibekov geneticcomponentofgreatgerbilssusceptibilitytoplagueinfection
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GENETIC COMPONENT OF GREAT GERBIL’S SUSCEPTIBILITY TO PLAGUE INFECTION

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