Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.

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Autores principales: Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a9888fc047054d7cb375efcf290854a4
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spelling oai:doaj.org-article:a9888fc047054d7cb375efcf290854a42021-12-02T18:37:28ZAfucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination10.1038/s41467-021-26118-w2041-1723https://doaj.org/article/a9888fc047054d7cb375efcf290854a42021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26118-whttps://doaj.org/toc/2041-1723Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.Mads Delbo LarsenMary Lopez-PerezEmmanuel Kakra DicksonPaulina AmpomahNicaise Tuikue NdamJan NoutaCarolien A. M. KoelemanAgnes L. Hipgrave EderveenBenjamin MordmüllerAli SalantiMorten Agertoug NielsenAchille MassougbodjiC. Ellen van der SchootMichael F. OforiManfred WuhrerLars HviidGestur VidarssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mads Delbo Larsen
Mary Lopez-Perez
Emmanuel Kakra Dickson
Paulina Ampomah
Nicaise Tuikue Ndam
Jan Nouta
Carolien A. M. Koeleman
Agnes L. Hipgrave Ederveen
Benjamin Mordmüller
Ali Salanti
Morten Agertoug Nielsen
Achille Massougbodji
C. Ellen van der Schoot
Michael F. Ofori
Manfred Wuhrer
Lars Hviid
Gestur Vidarsson
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
description Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.
format article
author Mads Delbo Larsen
Mary Lopez-Perez
Emmanuel Kakra Dickson
Paulina Ampomah
Nicaise Tuikue Ndam
Jan Nouta
Carolien A. M. Koeleman
Agnes L. Hipgrave Ederveen
Benjamin Mordmüller
Ali Salanti
Morten Agertoug Nielsen
Achille Massougbodji
C. Ellen van der Schoot
Michael F. Ofori
Manfred Wuhrer
Lars Hviid
Gestur Vidarsson
author_facet Mads Delbo Larsen
Mary Lopez-Perez
Emmanuel Kakra Dickson
Paulina Ampomah
Nicaise Tuikue Ndam
Jan Nouta
Carolien A. M. Koeleman
Agnes L. Hipgrave Ederveen
Benjamin Mordmüller
Ali Salanti
Morten Agertoug Nielsen
Achille Massougbodji
C. Ellen van der Schoot
Michael F. Ofori
Manfred Wuhrer
Lars Hviid
Gestur Vidarsson
author_sort Mads Delbo Larsen
title Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
title_short Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
title_full Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
title_fullStr Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
title_full_unstemmed Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
title_sort afucosylated plasmodium falciparum-specific igg is induced by infection but not by subunit vaccination
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a9888fc047054d7cb375efcf290854a4
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