Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.

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Autores principales: Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/a9888fc047054d7cb375efcf290854a4
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