VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila

Cells maintain a constant cytoplasm to nucleus volume ratio, although the role of DNA damage is not well explored. Here, the authors use Drosophila to connect TER94, the fly homolog of VCP, to disruption of DNA damage repair, leading to ubiquitinated Mu2 protein accumulation and enlarged nuclei.

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Autores principales:	Ya-Chu Chang, Yu-Xiang Peng, Bo-Hua Yu, Henry C. Chang, Pei-Shin Liang, Ting-Yi Huang, Chao-Jie Shih, Li-An Chu, Tzu-Kang Sang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a98e31b8568b4570a73299717fbf8dd4
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spelling	oai:doaj.org-article:a98e31b8568b4570a73299717fbf8dd42021-12-02T18:36:59ZVCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila10.1038/s41467-021-24556-02041-1723https://doaj.org/article/a98e31b8568b4570a73299717fbf8dd42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24556-0https://doaj.org/toc/2041-1723Cells maintain a constant cytoplasm to nucleus volume ratio, although the role of DNA damage is not well explored. Here, the authors use Drosophila to connect TER94, the fly homolog of VCP, to disruption of DNA damage repair, leading to ubiquitinated Mu2 protein accumulation and enlarged nuclei.Ya-Chu ChangYu-Xiang PengBo-Hua YuHenry C. ChangPei-Shin LiangTing-Yi HuangChao-Jie ShihLi-An ChuTzu-Kang SangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ya-Chu Chang Yu-Xiang Peng Bo-Hua Yu Henry C. Chang Pei-Shin Liang Ting-Yi Huang Chao-Jie Shih Li-An Chu Tzu-Kang Sang VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
description	Cells maintain a constant cytoplasm to nucleus volume ratio, although the role of DNA damage is not well explored. Here, the authors use Drosophila to connect TER94, the fly homolog of VCP, to disruption of DNA damage repair, leading to ubiquitinated Mu2 protein accumulation and enlarged nuclei.
format	article
author	Ya-Chu Chang Yu-Xiang Peng Bo-Hua Yu Henry C. Chang Pei-Shin Liang Ting-Yi Huang Chao-Jie Shih Li-An Chu Tzu-Kang Sang
author_facet	Ya-Chu Chang Yu-Xiang Peng Bo-Hua Yu Henry C. Chang Pei-Shin Liang Ting-Yi Huang Chao-Jie Shih Li-An Chu Tzu-Kang Sang
author_sort	Ya-Chu Chang
title	VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
title_short	VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
title_full	VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
title_fullStr	VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
title_full_unstemmed	VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
title_sort	vcp maintains nuclear size by regulating the dna damage-associated mdc1–p53–autophagy axis in drosophila
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a98e31b8568b4570a73299717fbf8dd4
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VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila

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