Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits

Objective: The present study is aimed to investigate the effects of administering a single intravenous dose of zoledronic acid (ZA) on bone healing following tooth extraction in ovariectomized rabbits. Materials and methods: Female, New Zealand rabbits were randomly divided into three groups includi...

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Autores principales:	Esra Mavi, Peyami Turgay Hocaoglu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bisphosphonates Zoledronic acid Ovariectomy Tooth extraction Medicine R Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/a993473afb16406bbf558af7b2d5c7b6
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spelling	oai:doaj.org-article:a993473afb16406bbf558af7b2d5c7b62021-11-10T04:18:08ZEffects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits1013-905210.1016/j.sdentj.2020.03.016https://doaj.org/article/a993473afb16406bbf558af7b2d5c7b62021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1013905219308041https://doaj.org/toc/1013-9052Objective: The present study is aimed to investigate the effects of administering a single intravenous dose of zoledronic acid (ZA) on bone healing following tooth extraction in ovariectomized rabbits. Materials and methods: Female, New Zealand rabbits were randomly divided into three groups including Control, ovariectomy + saline (OVX) and ovariectomy + zoledronic acid group (ZOL). Bilateral ovariectomy was performed to the rabbits in OVX and ZOL groups under general anesthesia. Control group underwent sham surgery. Eight weeks later, mandibular right incisors of all animals were extracted under general anesthesia. Before the procedure, Control and OVX groups were given saline and 0.1 mg/kg ZA was administered to ZOL group intravenously. All animals were sacrificed after 12 weeks. Results: The findings of histopathological and biochemical evaluations reflected insignificant differences among study groups in vascular endothelial growth factor (VEGF), increases in osteoclasts, ossification, vascularization and mononuclear cell infiltration measures (p > 0.05). In contrast, bone morphogenic protein 2 (BMP-2), tumor necrosis factor alpha (TNF-α) and organization of the extraction wound differed significantly between groups (p < 0.05) Conclusion: The potential beneficial effects of ZA administration on the wound healing process following tooth extraction were demonstrated via serum TNF-α, BMP-2 and VEGF levels in an osteoporotic model in ovariectomized rabbits.Esra MaviPeyami Turgay HocaogluElsevierarticleBisphosphonatesZoledronic acidOvariectomyTooth extractionMedicineRDentistryRK1-715ENSaudi Dental Journal, Vol 33, Iss 7, Pp 724-730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bisphosphonates Zoledronic acid Ovariectomy Tooth extraction Medicine R Dentistry RK1-715
spellingShingle	Bisphosphonates Zoledronic acid Ovariectomy Tooth extraction Medicine R Dentistry RK1-715 Esra Mavi Peyami Turgay Hocaoglu Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
description	Objective: The present study is aimed to investigate the effects of administering a single intravenous dose of zoledronic acid (ZA) on bone healing following tooth extraction in ovariectomized rabbits. Materials and methods: Female, New Zealand rabbits were randomly divided into three groups including Control, ovariectomy + saline (OVX) and ovariectomy + zoledronic acid group (ZOL). Bilateral ovariectomy was performed to the rabbits in OVX and ZOL groups under general anesthesia. Control group underwent sham surgery. Eight weeks later, mandibular right incisors of all animals were extracted under general anesthesia. Before the procedure, Control and OVX groups were given saline and 0.1 mg/kg ZA was administered to ZOL group intravenously. All animals were sacrificed after 12 weeks. Results: The findings of histopathological and biochemical evaluations reflected insignificant differences among study groups in vascular endothelial growth factor (VEGF), increases in osteoclasts, ossification, vascularization and mononuclear cell infiltration measures (p > 0.05). In contrast, bone morphogenic protein 2 (BMP-2), tumor necrosis factor alpha (TNF-α) and organization of the extraction wound differed significantly between groups (p < 0.05) Conclusion: The potential beneficial effects of ZA administration on the wound healing process following tooth extraction were demonstrated via serum TNF-α, BMP-2 and VEGF levels in an osteoporotic model in ovariectomized rabbits.
format	article
author	Esra Mavi Peyami Turgay Hocaoglu
author_facet	Esra Mavi Peyami Turgay Hocaoglu
author_sort	Esra Mavi
title	Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
title_short	Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
title_full	Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
title_fullStr	Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
title_full_unstemmed	Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
title_sort	effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a993473afb16406bbf558af7b2d5c7b6
work_keys_str_mv	AT esramavi effectsofasingleintravaneousdoseofzoledronicacidonbonehealingfollowingtoothextractioninovariectomizedrabbits AT peyamiturgayhocaoglu effectsofasingleintravaneousdoseofzoledronicacidonbonehealingfollowingtoothextractioninovariectomizedrabbits
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Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits

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