Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.

<h4>Background</h4>Several risk factors for depression during pregnancy have already been established. However, very few studies have conducted a multivariate analysis incorporating both the major predictors of depression in women, in accordance with comprehensive developmental models of...

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Autores principales:	Jacques Dayan, Christian Creveuil, Michel Dreyfus, Michel Herlicoviez, Jean-Marc Baleyte, Veronica O'Keane
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a999091ac3134eeea72ab01f8c3cbc2a
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spelling	oai:doaj.org-article:a999091ac3134eeea72ab01f8c3cbc2a2021-11-18T06:34:54ZDevelopmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.1932-620310.1371/journal.pone.0012942https://doaj.org/article/a999091ac3134eeea72ab01f8c3cbc2a2010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877652/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several risk factors for depression during pregnancy have already been established. However, very few studies have conducted a multivariate analysis incorporating both the major predictors of depression in women, in accordance with comprehensive developmental models of depression, and specific stressors associated with the biological and psychosocial state of the mother-to-be.<h4>Methodology/principal findings</h4>We used a cross-sectional cohort design to analyze the associations between prenatal depression and potential risk factors. 693 French-speaking women with singleton pregnancies at 20-28 weeks' gestation were consecutively recruited at Caen University Hospital. Fifty women with missing values were subsequently excluded from the analysis. Depressive symptoms were assessed on the Edinburgh Postnatal Depression Scale. Risk factors were either extracted from the computerized obstetric records or assessed by means of self-administered questionnaires. The associations between prenatal depression and the potential risk factors were assessed using log-binomial regression models to obtain a direct estimate of relative risk (RR). The following factors were found to be significant in the multivariate analysis: level of education (p<0.001), past psychiatric history (adjusted RR=1.8, 95% confidence interval (CI): 1.1;2.8, p=0.014), stress related to the health and viability of the fetus (adjusted RR=2.6, 95% CI: 1.6;4.1, p<0.001), and stress related to severe marital conflicts (adjusted RR=2.4, 95% CI: 1.5;3.9, p<0.001) or to serious difficulties at work (adjusted RR=1.6, 95% CI :1.04;2.4, p=0.031). An association was also found with the previous delivery of a child with a major or minor birth defect (adjusted RR=2.0, 95% CI: 1.04;4.0, p=0.038). Univariate analyses revealed a strong association with childhood adversity (parental rejection: RR=1.8, 95% CI: 1.2;2.8, p=0.0055 and family secrets: RR=2.0, 95% CI: 1.2;3.1, p=0.0046) and with lack of partner support (RR=0.50, 95% CI: 0.30;0.84, p=0.0086).<h4>Conclusions/significance</h4>Our study identifies several risk factors that could easily be assessed in clinical practice. It draws attention to the impact of previously delivering a child with a birth defect. The association with childhood adversity warrants further study.Jacques DayanChristian CreveuilMichel DreyfusMichel HerlicoviezJean-Marc BaleyteVeronica O'KeanePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12942 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jacques Dayan Christian Creveuil Michel Dreyfus Michel Herlicoviez Jean-Marc Baleyte Veronica O'Keane Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
description	<h4>Background</h4>Several risk factors for depression during pregnancy have already been established. However, very few studies have conducted a multivariate analysis incorporating both the major predictors of depression in women, in accordance with comprehensive developmental models of depression, and specific stressors associated with the biological and psychosocial state of the mother-to-be.<h4>Methodology/principal findings</h4>We used a cross-sectional cohort design to analyze the associations between prenatal depression and potential risk factors. 693 French-speaking women with singleton pregnancies at 20-28 weeks' gestation were consecutively recruited at Caen University Hospital. Fifty women with missing values were subsequently excluded from the analysis. Depressive symptoms were assessed on the Edinburgh Postnatal Depression Scale. Risk factors were either extracted from the computerized obstetric records or assessed by means of self-administered questionnaires. The associations between prenatal depression and the potential risk factors were assessed using log-binomial regression models to obtain a direct estimate of relative risk (RR). The following factors were found to be significant in the multivariate analysis: level of education (p<0.001), past psychiatric history (adjusted RR=1.8, 95% confidence interval (CI): 1.1;2.8, p=0.014), stress related to the health and viability of the fetus (adjusted RR=2.6, 95% CI: 1.6;4.1, p<0.001), and stress related to severe marital conflicts (adjusted RR=2.4, 95% CI: 1.5;3.9, p<0.001) or to serious difficulties at work (adjusted RR=1.6, 95% CI :1.04;2.4, p=0.031). An association was also found with the previous delivery of a child with a major or minor birth defect (adjusted RR=2.0, 95% CI: 1.04;4.0, p=0.038). Univariate analyses revealed a strong association with childhood adversity (parental rejection: RR=1.8, 95% CI: 1.2;2.8, p=0.0055 and family secrets: RR=2.0, 95% CI: 1.2;3.1, p=0.0046) and with lack of partner support (RR=0.50, 95% CI: 0.30;0.84, p=0.0086).<h4>Conclusions/significance</h4>Our study identifies several risk factors that could easily be assessed in clinical practice. It draws attention to the impact of previously delivering a child with a birth defect. The association with childhood adversity warrants further study.
format	article
author	Jacques Dayan Christian Creveuil Michel Dreyfus Michel Herlicoviez Jean-Marc Baleyte Veronica O'Keane
author_facet	Jacques Dayan Christian Creveuil Michel Dreyfus Michel Herlicoviez Jean-Marc Baleyte Veronica O'Keane
author_sort	Jacques Dayan
title	Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
title_short	Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
title_full	Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
title_fullStr	Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
title_full_unstemmed	Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
title_sort	developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/a999091ac3134eeea72ab01f8c3cbc2a
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Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress.

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