Novel therapeutic strategies for patients with metastatic triple-negative breast cancer

Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer. In the presence of distant metastases, the median overall survival does not exceed 14 months. TNBC is an extremely heterogeneous group of tumors, it includes both tumors extremely sensitive to chemotherapy and...

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Autores principales: Inna P. Ganshina, Olga O. Gordeeva, Mariam Sh. Manukian
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Lenguaje:RU
Publicado: IP Habib O.N. 2021
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Acceso en línea:https://doaj.org/article/a99aa8bbbad543218bc93d48c8adcbf6
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spelling oai:doaj.org-article:a99aa8bbbad543218bc93d48c8adcbf62021-11-30T17:03:34ZNovel therapeutic strategies for patients with metastatic triple-negative breast cancer1815-14341815-144210.26442/18151434.2020.4.200495https://doaj.org/article/a99aa8bbbad543218bc93d48c8adcbf62021-02-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/61149/44238https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer. In the presence of distant metastases, the median overall survival does not exceed 14 months. TNBC is an extremely heterogeneous group of tumors, it includes both tumors extremely sensitive to chemotherapy and tumors that require targeted or immunotherapy for the best treatment outcomes. Such subtype features make it difficult to develop a single treatment strategy for all patients. Current perceptions of resistance mechanisms and molecular drivers progression have increased therapeutic opportunities for metastatic TNBC (mTNBC). For example, in the last few years, checkpoint inhibitors and PARP inhibitors have entered into clinical practice in the Russian Federation. This review presents clinical trial data, as well as an algorithm for choosing therapy for patients with TNBC, based on the results of recent clinical studies. The review focuses mainly on drugs registered at the territory of the Russian Federation, that allows to apply these options in everyday clinical practice. Promising directions therapy of mTNBC not registered at the territory of the Russian Federation yet will be showed in a separate review in the next issue in the Journal of Modern Oncology.Inna P. GanshinaOlga O. GordeevaMariam Sh. ManukianIP Habib O.N.articletriple negative breast cancerchemotherapyantiangiogenic therapyimmunotherapyparp inhibitorsdrug therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 4, Pp 60-65 (2021)
institution DOAJ
collection DOAJ
language RU
topic triple negative breast cancer
chemotherapy
antiangiogenic therapy
immunotherapy
parp inhibitors
drug therapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle triple negative breast cancer
chemotherapy
antiangiogenic therapy
immunotherapy
parp inhibitors
drug therapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Inna P. Ganshina
Olga O. Gordeeva
Mariam Sh. Manukian
Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
description Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer. In the presence of distant metastases, the median overall survival does not exceed 14 months. TNBC is an extremely heterogeneous group of tumors, it includes both tumors extremely sensitive to chemotherapy and tumors that require targeted or immunotherapy for the best treatment outcomes. Such subtype features make it difficult to develop a single treatment strategy for all patients. Current perceptions of resistance mechanisms and molecular drivers progression have increased therapeutic opportunities for metastatic TNBC (mTNBC). For example, in the last few years, checkpoint inhibitors and PARP inhibitors have entered into clinical practice in the Russian Federation. This review presents clinical trial data, as well as an algorithm for choosing therapy for patients with TNBC, based on the results of recent clinical studies. The review focuses mainly on drugs registered at the territory of the Russian Federation, that allows to apply these options in everyday clinical practice. Promising directions therapy of mTNBC not registered at the territory of the Russian Federation yet will be showed in a separate review in the next issue in the Journal of Modern Oncology.
format article
author Inna P. Ganshina
Olga O. Gordeeva
Mariam Sh. Manukian
author_facet Inna P. Ganshina
Olga O. Gordeeva
Mariam Sh. Manukian
author_sort Inna P. Ganshina
title Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
title_short Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
title_full Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
title_fullStr Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
title_full_unstemmed Novel therapeutic strategies for patients with metastatic triple-negative breast cancer
title_sort novel therapeutic strategies for patients with metastatic triple-negative breast cancer
publisher IP Habib O.N.
publishDate 2021
url https://doaj.org/article/a99aa8bbbad543218bc93d48c8adcbf6
work_keys_str_mv AT innapganshina noveltherapeuticstrategiesforpatientswithmetastatictriplenegativebreastcancer
AT olgaogordeeva noveltherapeuticstrategiesforpatientswithmetastatictriplenegativebreastcancer
AT mariamshmanukian noveltherapeuticstrategiesforpatientswithmetastatictriplenegativebreastcancer
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