Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a99beedee95f4504bd782063edbc7711
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a99beedee95f4504bd782063edbc7711
record_format	dspace
spelling	oai:doaj.org-article:a99beedee95f4504bd782063edbc77112021-11-21T12:34:43ZSoluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer10.1038/s41467-021-26823-62041-1723https://doaj.org/article/a99beedee95f4504bd782063edbc77112021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26823-6https://doaj.org/toc/2041-1723The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.Maximilian W. SchenkSam HumphreyA. S. Md Mukarram HossainMitchell RevillSarah PearsallAlice LalloStewart BrownSamuel BrattMelanie GalvinTine DescampsCong ZhouSimon P. PearceLynsey PriestMichelle GreenhalghAnshuman ChaturvediAlastair KerrFiona BlackhallCaroline DiveKristopher K. FreseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maximilian W. Schenk Sam Humphrey A. S. Md Mukarram Hossain Mitchell Revill Sarah Pearsall Alice Lallo Stewart Brown Samuel Bratt Melanie Galvin Tine Descamps Cong Zhou Simon P. Pearce Lynsey Priest Michelle Greenhalgh Anshuman Chaturvedi Alastair Kerr Fiona Blackhall Caroline Dive Kristopher K. Frese Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
description	The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.
format	article
author	Maximilian W. Schenk Sam Humphrey A. S. Md Mukarram Hossain Mitchell Revill Sarah Pearsall Alice Lallo Stewart Brown Samuel Bratt Melanie Galvin Tine Descamps Cong Zhou Simon P. Pearce Lynsey Priest Michelle Greenhalgh Anshuman Chaturvedi Alastair Kerr Fiona Blackhall Caroline Dive Kristopher K. Frese
author_facet	Maximilian W. Schenk Sam Humphrey A. S. Md Mukarram Hossain Mitchell Revill Sarah Pearsall Alice Lallo Stewart Brown Samuel Bratt Melanie Galvin Tine Descamps Cong Zhou Simon P. Pearce Lynsey Priest Michelle Greenhalgh Anshuman Chaturvedi Alastair Kerr Fiona Blackhall Caroline Dive Kristopher K. Frese
author_sort	Maximilian W. Schenk
title	Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
title_short	Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
title_full	Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
title_fullStr	Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
title_full_unstemmed	Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
title_sort	soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a99beedee95f4504bd782063edbc7711
work_keys_str_mv	AT maximilianwschenk solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT samhumphrey solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT asmdmukarramhossain solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT mitchellrevill solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT sarahpearsall solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT alicelallo solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT stewartbrown solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT samuelbratt solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT melaniegalvin solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT tinedescamps solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT congzhou solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT simonppearce solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT lynseypriest solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT michellegreenhalgh solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT anshumanchaturvedi solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT alastairkerr solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT fionablackhall solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT carolinedive solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer AT kristopherkfrese solubleguanylatecyclasesignallingmediatesetoposideresistanceinprogressingsmallcelllungcancer
_version_	1718418906277740544

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Ejemplares similares