Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disea...
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2018
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oai:doaj.org-article:a99d2484d9a048f3ab41a8a1d889ba682021-12-02T14:39:25ZGenome-wide association meta-analysis yields 20 loci associated with gallstone disease10.1038/s41467-018-07460-y2041-1723https://doaj.org/article/a99d2484d9a048f3ab41a8a1d889ba682018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07460-yhttps://doaj.org/toc/2041-1723Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease.Egil FerkingstadAsmundur OddssonSolveig GretarsdottirStefania BenonisdottirGudmar ThorleifssonAimee M. DeatonStefan JonssonOlafur A. StefanssonGudmundur L. NorddahlFlorian ZinkGudny A. ArnadottirBjarni GunnarssonGisli H. HalldorssonAnna HelgadottirBrynjar O. JenssonRagnar P. KristjanssonGardar SveinbjornssonDavid A. SverrissonGisli MassonIsleifur OlafssonGudmundur I. EyjolfssonOlof SigurdardottirHilma HolmIngileif JonsdottirSigurdur OlafssonThora SteingrimsdottirThorunn RafnarEinar S. BjornssonUnnur ThorsteinsdottirDaniel F. GudbjartssonPatrick SulemKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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DOAJ |
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EN |
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Science Q |
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Science Q Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| description |
Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease. |
| format |
article |
| author |
Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson |
| author_facet |
Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson |
| author_sort |
Egil Ferkingstad |
| title |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| title_short |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| title_full |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| title_fullStr |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| title_full_unstemmed |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| title_sort |
genome-wide association meta-analysis yields 20 loci associated with gallstone disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a99d2484d9a048f3ab41a8a1d889ba68 |
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