Changes in effective connectivity by propofol sedation.

Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics obse...

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Autores principales:	Francisco Gómez, Christophe Phillips, Andrea Soddu, Melanie Boly, Pierre Boveroux, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno, Olivia Gosseries, Vincent Bonhomme, Steven Laureys, Quentin Noirhomme
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a99fd61d40b547a4807e2a6a49654554
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spelling	oai:doaj.org-article:a99fd61d40b547a4807e2a6a496545542021-11-18T08:59:10ZChanges in effective connectivity by propofol sedation.1932-620310.1371/journal.pone.0071370https://doaj.org/article/a99fd61d40b547a4807e2a6a496545542013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977030/?tool=EBIhttps://doaj.org/toc/1932-6203Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices.Francisco GómezChristophe PhillipsAndrea SodduMelanie BolyPierre BoverouxAudrey VanhaudenhuyseMarie-Aurélie BrunoOlivia GosseriesVincent BonhommeSteven LaureysQuentin NoirhommePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71370 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco Gómez Christophe Phillips Andrea Soddu Melanie Boly Pierre Boveroux Audrey Vanhaudenhuyse Marie-Aurélie Bruno Olivia Gosseries Vincent Bonhomme Steven Laureys Quentin Noirhomme Changes in effective connectivity by propofol sedation.
description	Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices.
format	article
author	Francisco Gómez Christophe Phillips Andrea Soddu Melanie Boly Pierre Boveroux Audrey Vanhaudenhuyse Marie-Aurélie Bruno Olivia Gosseries Vincent Bonhomme Steven Laureys Quentin Noirhomme
author_facet	Francisco Gómez Christophe Phillips Andrea Soddu Melanie Boly Pierre Boveroux Audrey Vanhaudenhuyse Marie-Aurélie Bruno Olivia Gosseries Vincent Bonhomme Steven Laureys Quentin Noirhomme
author_sort	Francisco Gómez
title	Changes in effective connectivity by propofol sedation.
title_short	Changes in effective connectivity by propofol sedation.
title_full	Changes in effective connectivity by propofol sedation.
title_fullStr	Changes in effective connectivity by propofol sedation.
title_full_unstemmed	Changes in effective connectivity by propofol sedation.
title_sort	changes in effective connectivity by propofol sedation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a99fd61d40b547a4807e2a6a49654554
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_version_	1718421103043411968

Changes in effective connectivity by propofol sedation.

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