Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain Delivery: Evaluation and Nasal Ciliotoxicity Studies

Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain Delivery: Evaluation and Nasal Ciliotoxicity Studies

Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the management of demented conditions associated with Alzheimer disease. The major hurdle of delivering this drug through the oral route is its poor bioavailability, which prompted the development of novel delivery appro...

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Bibliographic Details
Main Authors: Mansi Bhanderi, Jigar Shah, Bapi Gorain, Anroop B. Nair, Shery Jacob, Syed Mohammed Basheeruddin Asdaq, Santosh Fattepur, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Sreeharsha Nagaraja, Md. Khalid Anwer
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
nanoparticles
rivastigmine
intranasal application
optimization
quality by design
Technology
T
Electrical engineering. Electronics. Nuclear engineering
TK1-9971
Engineering (General). Civil engineering (General)
TA1-2040
Microscopy
QH201-278.5
Descriptive and experimental mechanics
QC120-168.85
Online Access:https://doaj.org/article/a9a7af170d3740dbb93f81d5536f7331
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