Binding fullerenol C60(OH)24 to dsDNA

Binding fullerenol C60(OH)24 to dsDNA

Mariana Pinteala, Andrei Dascalu, Cezar UngurenasuPetru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, RomaniaAbstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion t...

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Main Authors: Mariana Pinteala, Andrei Dascalu, Cezar Ungurenasu
Format: article
Language:EN
Published: Dove Medical Press 2009
Subjects:
Medicine (General)
R5-920
Online Access:https://doaj.org/article/a9abd9a58f0a4b33a8b9bd48e5c4ea0b
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spelling oai:doaj.org-article:a9abd9a58f0a4b33a8b9bd48e5c4ea0b2021-12-02T03:54:01ZBinding fullerenol C60(OH)24 to dsDNA1176-91141178-2013https://doaj.org/article/a9abd9a58f0a4b33a8b9bd48e5c4ea0b2009-09-01T00:00:00Zhttp://www.dovepress.com/binding-fullerenol-c60oh24-to-dsdna-a3522https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mariana Pinteala, Andrei Dascalu, Cezar UngurenasuPetru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, RomaniaAbstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion to the concentration of DNA in the range of 1 × 10-9 to 8 × 10-5 molL-1 and the detection limit was 1.3 ng mL-1. Fullerenol C60(OH)24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.Keywords: nanomedicine, fullerenol, DNA complexation, fluorescent probe Mariana PintealaAndrei DascaluCezar UngurenasuDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 193-199 (2009)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Mariana Pinteala
Andrei Dascalu
Cezar Ungurenasu
Binding fullerenol C60(OH)24 to dsDNA
description Mariana Pinteala, Andrei Dascalu, Cezar UngurenasuPetru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, RomaniaAbstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion to the concentration of DNA in the range of 1 × 10-9 to 8 × 10-5 molL-1 and the detection limit was 1.3 ng mL-1. Fullerenol C60(OH)24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.Keywords: nanomedicine, fullerenol, DNA complexation, fluorescent probe
format article
author Mariana Pinteala
Andrei Dascalu
Cezar Ungurenasu
author_facet Mariana Pinteala
Andrei Dascalu
Cezar Ungurenasu
author_sort Mariana Pinteala
title Binding fullerenol C60(OH)24 to dsDNA
title_short Binding fullerenol C60(OH)24 to dsDNA
title_full Binding fullerenol C60(OH)24 to dsDNA
title_fullStr Binding fullerenol C60(OH)24 to dsDNA
title_full_unstemmed Binding fullerenol C60(OH)24 to dsDNA
title_sort binding fullerenol c60(oh)24 to dsdna
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/a9abd9a58f0a4b33a8b9bd48e5c4ea0b
work_keys_str_mv AT marianapinteala bindingfullerenolc60oh24todsdna
AT andreidascalu bindingfullerenolc60oh24todsdna
AT cezarungurenasu bindingfullerenolc60oh24todsdna
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