Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.

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Auteurs principaux:	Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a03
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spelling	oai:doaj.org-article:a9accbe2206844e88e73f54fa7b62a032021-12-02T14:41:22ZDiscovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes10.1038/s41467-017-01575-42041-1723https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a032017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01575-4https://doaj.org/toc/2041-1723The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.Nadine Ait-BouziadGuohua LvAnne-Laure Mahul-MellierShifeng XiaoGizem ZorludemirDavid EliezerThomas WalzHilal A. LashuelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
description	The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.
format	article
author	Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel
author_facet	Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel
author_sort	Nadine Ait-Bouziad
title	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_short	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_full	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_fullStr	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_full_unstemmed	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_sort	discovery and characterization of stable and toxic tau/phospholipid oligomeric complexes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a03
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Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

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