Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links....

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Autores principales:	Gabriela E. Davey, Zenita Adhireksan, Zhujun Ma, Tina Riedel, Deepti Sharma, Sivaraman Padavattan, Daniela Rhodes, Alexander Ludwig, Sara Sandin, Benjamin S. Murray, Paul J. Dyson, Curt A. Davey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9b55ad0f6804689b89dc6a03944e55c
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spelling	oai:doaj.org-article:a9b55ad0f6804689b89dc6a03944e55c2021-12-02T14:41:19ZNucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation10.1038/s41467-017-01680-42041-1723https://doaj.org/article/a9b55ad0f6804689b89dc6a03944e55c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01680-4https://doaj.org/toc/2041-1723Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links.Gabriela E. DaveyZenita AdhireksanZhujun MaTina RiedelDeepti SharmaSivaraman PadavattanDaniela RhodesAlexander LudwigSara SandinBenjamin S. MurrayPaul J. DysonCurt A. DaveyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriela E. Davey Zenita Adhireksan Zhujun Ma Tina Riedel Deepti Sharma Sivaraman Padavattan Daniela Rhodes Alexander Ludwig Sara Sandin Benjamin S. Murray Paul J. Dyson Curt A. Davey Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
description	Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links.
format	article
author	Gabriela E. Davey Zenita Adhireksan Zhujun Ma Tina Riedel Deepti Sharma Sivaraman Padavattan Daniela Rhodes Alexander Ludwig Sara Sandin Benjamin S. Murray Paul J. Dyson Curt A. Davey
author_facet	Gabriela E. Davey Zenita Adhireksan Zhujun Ma Tina Riedel Deepti Sharma Sivaraman Padavattan Daniela Rhodes Alexander Ludwig Sara Sandin Benjamin S. Murray Paul J. Dyson Curt A. Davey
author_sort	Gabriela E. Davey
title	Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
title_short	Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
title_full	Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
title_fullStr	Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
title_full_unstemmed	Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
title_sort	nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9b55ad0f6804689b89dc6a03944e55c
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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

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