Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links....

Full description

Saved in:
Bibliographic Details
Main Authors: Gabriela E. Davey, Zenita Adhireksan, Zhujun Ma, Tina Riedel, Deepti Sharma, Sivaraman Padavattan, Daniela Rhodes, Alexander Ludwig, Sara Sandin, Benjamin S. Murray, Paul J. Dyson, Curt A. Davey
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/a9b55ad0f6804689b89dc6a03944e55c
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/a9b55ad0f6804689b89dc6a03944e55c

Similar Items