Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)

This study aimed to identify the effectiveness of SNEDDS of Pegagan Leaf Ethanol Extract (PLE) to reduce fasting blood glucose (FBG) levels in zebrafish. Centella asiatica (L.) Urb. or pegagan is among the medicinal plants widely used to treat diabetes in Indonesia. Maceration was employed with 70%...

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Autores principales:	Hayati Farida, Chabib Lutfi, Sekarraras Faiza Dea, Faizah Wan Syarifah
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	centella asiatica hyperglycemia snedds zebrafish danio rerio diabetes Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a9b6d877851c4636b2b39b4b368234c9
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spelling	oai:doaj.org-article:a9b6d877851c4636b2b39b4b368234c92021-12-05T14:10:44ZAntihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)2391-542010.1515/chem-2021-0200https://doaj.org/article/a9b6d877851c4636b2b39b4b368234c92021-02-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0200https://doaj.org/toc/2391-5420This study aimed to identify the effectiveness of SNEDDS of Pegagan Leaf Ethanol Extract (PLE) to reduce fasting blood glucose (FBG) levels in zebrafish. Centella asiatica (L.) Urb. or pegagan is among the medicinal plants widely used to treat diabetes in Indonesia. Maceration was employed with 70% ethanol to obtain a viscous extract for the formulation of SNEDDS with Capryol 90, Tween 80, and PEG 400 (1:6:3). Antihyperglycemic testing was conducted on five groups, consisting of normal, positive control, negative control, P I treatment, and P II treatment. On Day 1, all except the normal group was induced with 300 mg alloxan and soaked in 2% glucose solution for 7 days. On day 8, the treatment consisted of 25 mg/2 L metformin for the positive control, 100 mg/2 L SNEDDS for P I, 200 mg/2 L SNEDDS for P II, and no treatment for the negative control. The SNEDDS characterization obtained 100.6 ± 3.12 nm particle size and −7.93 ± 0.66 mV zeta potential, indicating that the SNEDDS had fulfilled the requirements of good preparation. The antidiabetic activity test found a 69.90% decline in FBG levels in 100 mg/2 L SNEDDS and 72.20% in 200 mg/2 L SNEDDS.Hayati FaridaChabib LutfiSekarraras Faiza DeaFaizah Wan SyarifahDe Gruyterarticlecentella asiaticahyperglycemiasneddszebrafishdanio reriodiabetesChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 184-188 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	centella asiatica hyperglycemia snedds zebrafish danio rerio diabetes Chemistry QD1-999
spellingShingle	centella asiatica hyperglycemia snedds zebrafish danio rerio diabetes Chemistry QD1-999 Hayati Farida Chabib Lutfi Sekarraras Faiza Dea Faizah Wan Syarifah Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
description	This study aimed to identify the effectiveness of SNEDDS of Pegagan Leaf Ethanol Extract (PLE) to reduce fasting blood glucose (FBG) levels in zebrafish. Centella asiatica (L.) Urb. or pegagan is among the medicinal plants widely used to treat diabetes in Indonesia. Maceration was employed with 70% ethanol to obtain a viscous extract for the formulation of SNEDDS with Capryol 90, Tween 80, and PEG 400 (1:6:3). Antihyperglycemic testing was conducted on five groups, consisting of normal, positive control, negative control, P I treatment, and P II treatment. On Day 1, all except the normal group was induced with 300 mg alloxan and soaked in 2% glucose solution for 7 days. On day 8, the treatment consisted of 25 mg/2 L metformin for the positive control, 100 mg/2 L SNEDDS for P I, 200 mg/2 L SNEDDS for P II, and no treatment for the negative control. The SNEDDS characterization obtained 100.6 ± 3.12 nm particle size and −7.93 ± 0.66 mV zeta potential, indicating that the SNEDDS had fulfilled the requirements of good preparation. The antidiabetic activity test found a 69.90% decline in FBG levels in 100 mg/2 L SNEDDS and 72.20% in 200 mg/2 L SNEDDS.
format	article
author	Hayati Farida Chabib Lutfi Sekarraras Faiza Dea Faizah Wan Syarifah
author_facet	Hayati Farida Chabib Lutfi Sekarraras Faiza Dea Faizah Wan Syarifah
author_sort	Hayati Farida
title	Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
title_short	Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
title_full	Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
title_fullStr	Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
title_full_unstemmed	Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)
title_sort	antihyperglycemic activity of centella asiatica (l.) urb. leaf ethanol extract snedds in zebrafish (danio rerio)
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a9b6d877851c4636b2b39b4b368234c9
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Antihyperglycemic activity of Centella asiatica (L.) Urb. leaf ethanol extract SNEDDS in zebrafish (Danio rerio)

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