A novel parameter derived from post-processing procedure of dual energy CT for identification of gout

Abstract ROI analysis is frequently used for obtaining acid content on rapid-kV-switching dual energy CT (DECT), providing inadequate accuracy. A new parameter derived from post-processing procedure, maximum lower limit with stain visible (MLLSV), was used by us to diagnose gout. 30 gout patients an...

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Autores principales:	Chunlin Xiang, Hongyan Zhang, Gang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9b70129afd64ebca8a87c7d6185b3f4
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spelling	oai:doaj.org-article:a9b70129afd64ebca8a87c7d6185b3f42021-11-08T10:55:59ZA novel parameter derived from post-processing procedure of dual energy CT for identification of gout10.1038/s41598-021-01100-02045-2322https://doaj.org/article/a9b70129afd64ebca8a87c7d6185b3f42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01100-0https://doaj.org/toc/2045-2322Abstract ROI analysis is frequently used for obtaining acid content on rapid-kV-switching dual energy CT (DECT), providing inadequate accuracy. A new parameter derived from post-processing procedure, maximum lower limit with stain visible (MLLSV), was used by us to diagnose gout. 30 gout patients and 20 healthy volunteers were analyzed by using MLLSV. MLLSV was defined as the maximum lower limit of display window allowing only one stained site visible. Radiologists were asked to continuously increase the lower limit of display window of uric acid to decrease number of stained sites until the last stained site disappeared. MLLSV obtained by this way was compared between gout patients and volunteers. Receiver operating characteristic (ROC) curve was used to determine the performance. MLLSV of gout patients was significantly higher than that of volunteers (1373.3 ± 23.0 mg/cm3 vs. 1315.4 ± 20.7 mg/cm3, p = 0.000). The area under ROC curve of MLLSV was 0.993 in identifying gout. When using the optimal cutoff of 1342 mg/cm3, the sensitivity and specificity of MLLSV in identification of gout were 96.7% and 95% respectively. MLLSV derived from post-processing procedure of DECT is useful in discriminating gout patients from healthy people.Chunlin XiangHongyan ZhangGang WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chunlin Xiang Hongyan Zhang Gang Wu A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
description	Abstract ROI analysis is frequently used for obtaining acid content on rapid-kV-switching dual energy CT (DECT), providing inadequate accuracy. A new parameter derived from post-processing procedure, maximum lower limit with stain visible (MLLSV), was used by us to diagnose gout. 30 gout patients and 20 healthy volunteers were analyzed by using MLLSV. MLLSV was defined as the maximum lower limit of display window allowing only one stained site visible. Radiologists were asked to continuously increase the lower limit of display window of uric acid to decrease number of stained sites until the last stained site disappeared. MLLSV obtained by this way was compared between gout patients and volunteers. Receiver operating characteristic (ROC) curve was used to determine the performance. MLLSV of gout patients was significantly higher than that of volunteers (1373.3 ± 23.0 mg/cm3 vs. 1315.4 ± 20.7 mg/cm3, p = 0.000). The area under ROC curve of MLLSV was 0.993 in identifying gout. When using the optimal cutoff of 1342 mg/cm3, the sensitivity and specificity of MLLSV in identification of gout were 96.7% and 95% respectively. MLLSV derived from post-processing procedure of DECT is useful in discriminating gout patients from healthy people.
format	article
author	Chunlin Xiang Hongyan Zhang Gang Wu
author_facet	Chunlin Xiang Hongyan Zhang Gang Wu
author_sort	Chunlin Xiang
title	A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
title_short	A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
title_full	A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
title_fullStr	A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
title_full_unstemmed	A novel parameter derived from post-processing procedure of dual energy CT for identification of gout
title_sort	novel parameter derived from post-processing procedure of dual energy ct for identification of gout
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a9b70129afd64ebca8a87c7d6185b3f4
work_keys_str_mv	AT chunlinxiang anovelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout AT hongyanzhang anovelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout AT gangwu anovelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout AT chunlinxiang novelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout AT hongyanzhang novelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout AT gangwu novelparameterderivedfrompostprocessingprocedureofdualenergyctforidentificationofgout
_version_	1718442555779055616

A novel parameter derived from post-processing procedure of dual energy CT for identification of gout

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