Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/a9b9f94f37144c97936aee7cddb44bba |
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oai:doaj.org-article:a9b9f94f37144c97936aee7cddb44bba2021-12-02T15:34:30ZSpecifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice10.1038/ncomms106182041-1723https://doaj.org/article/a9b9f94f37144c97936aee7cddb44bba2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10618https://doaj.org/toc/2041-1723The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse modelAndrew T. McGuireMatthew D. GrayPia DosenovicAlexander D. GitlinNatalia T. FreundJohn PetersenColin CorrentiWilliam JohnsenRobert KegelAndrew B. StuartJolene GlennMichael S. SeamanWilliam R. SchiefRoland K. StrongMichel C. NussenzweigLeonidas StamatatosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andrew T. McGuire Matthew D. Gray Pia Dosenovic Alexander D. Gitlin Natalia T. Freund John Petersen Colin Correnti William Johnsen Robert Kegel Andrew B. Stuart Jolene Glenn Michael S. Seaman William R. Schief Roland K. Strong Michel C. Nussenzweig Leonidas Stamatatos Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| description |
The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model |
| format |
article |
| author |
Andrew T. McGuire Matthew D. Gray Pia Dosenovic Alexander D. Gitlin Natalia T. Freund John Petersen Colin Correnti William Johnsen Robert Kegel Andrew B. Stuart Jolene Glenn Michael S. Seaman William R. Schief Roland K. Strong Michel C. Nussenzweig Leonidas Stamatatos |
| author_facet |
Andrew T. McGuire Matthew D. Gray Pia Dosenovic Alexander D. Gitlin Natalia T. Freund John Petersen Colin Correnti William Johnsen Robert Kegel Andrew B. Stuart Jolene Glenn Michael S. Seaman William R. Schief Roland K. Strong Michel C. Nussenzweig Leonidas Stamatatos |
| author_sort |
Andrew T. McGuire |
| title |
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| title_short |
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| title_full |
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| title_fullStr |
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| title_full_unstemmed |
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice |
| title_sort |
specifically modified env immunogens activate b-cell precursors of broadly neutralizing hiv-1 antibodies in transgenic mice |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/a9b9f94f37144c97936aee7cddb44bba |
| work_keys_str_mv |
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| _version_ |
1718386856283865088 |