Presence of tophi is associated with a rapid decline in the renal function in patients with gout

Abstract We aimed to compare clinical characteristics of patients with and without tophi at the time of the diagnosis of gout and investigate the association of tophi and renal function in gout patients. The patients who were first diagnosed with gout at the Kangwon National University Hospital were...

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Autores principales:	Yoon-Jeong Oh, Ki Won Moon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9bad1185850440aa48cd512da8c8013
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spelling	oai:doaj.org-article:a9bad1185850440aa48cd512da8c80132021-12-02T13:34:32ZPresence of tophi is associated with a rapid decline in the renal function in patients with gout10.1038/s41598-021-84980-62045-2322https://doaj.org/article/a9bad1185850440aa48cd512da8c80132021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84980-6https://doaj.org/toc/2045-2322Abstract We aimed to compare clinical characteristics of patients with and without tophi at the time of the diagnosis of gout and investigate the association of tophi and renal function in gout patients. The patients who were first diagnosed with gout at the Kangwon National University Hospital were retrospectively studied. Patients were divided into 2 groups according to the presence of tophi at the diagnosis. We compared clinical characteristics and the progression of renal dysfunction between the two groups. Of 276 patients, 66 (25.5%) initially presented with tophi. Tophi group was older, had a longer symptom duration, and a higher prevalence of multiple joint involvement than those without tophi. In multivariate logistic regression analysis, prolonged symptom duration and multiple joint involvement were significantly associated with increased risk of formation of tophi. The decline in the eGFR was more prominent in patients with tophi than in those without (− 4.8 ± 14.5 vs. − 0.7 ± 11.9 ml/min/1.73 m2/year, respectively; P = 0.039). The presence of tophi was significantly associated with a rapid decline in the eGFR (β = − 0.136; P = 0.042). In conclusion, the presence of tophi was associated with a rapid declining renal function. Therefore, an early diagnosis and closely monitoring of renal function might be important in gout patients with tophi.Yoon-Jeong OhKi Won MoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoon-Jeong Oh Ki Won Moon Presence of tophi is associated with a rapid decline in the renal function in patients with gout
description	Abstract We aimed to compare clinical characteristics of patients with and without tophi at the time of the diagnosis of gout and investigate the association of tophi and renal function in gout patients. The patients who were first diagnosed with gout at the Kangwon National University Hospital were retrospectively studied. Patients were divided into 2 groups according to the presence of tophi at the diagnosis. We compared clinical characteristics and the progression of renal dysfunction between the two groups. Of 276 patients, 66 (25.5%) initially presented with tophi. Tophi group was older, had a longer symptom duration, and a higher prevalence of multiple joint involvement than those without tophi. In multivariate logistic regression analysis, prolonged symptom duration and multiple joint involvement were significantly associated with increased risk of formation of tophi. The decline in the eGFR was more prominent in patients with tophi than in those without (− 4.8 ± 14.5 vs. − 0.7 ± 11.9 ml/min/1.73 m2/year, respectively; P = 0.039). The presence of tophi was significantly associated with a rapid decline in the eGFR (β = − 0.136; P = 0.042). In conclusion, the presence of tophi was associated with a rapid declining renal function. Therefore, an early diagnosis and closely monitoring of renal function might be important in gout patients with tophi.
format	article
author	Yoon-Jeong Oh Ki Won Moon
author_facet	Yoon-Jeong Oh Ki Won Moon
author_sort	Yoon-Jeong Oh
title	Presence of tophi is associated with a rapid decline in the renal function in patients with gout
title_short	Presence of tophi is associated with a rapid decline in the renal function in patients with gout
title_full	Presence of tophi is associated with a rapid decline in the renal function in patients with gout
title_fullStr	Presence of tophi is associated with a rapid decline in the renal function in patients with gout
title_full_unstemmed	Presence of tophi is associated with a rapid decline in the renal function in patients with gout
title_sort	presence of tophi is associated with a rapid decline in the renal function in patients with gout
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a9bad1185850440aa48cd512da8c8013
work_keys_str_mv	AT yoonjeongoh presenceoftophiisassociatedwitharapiddeclineintherenalfunctioninpatientswithgout AT kiwonmoon presenceoftophiisassociatedwitharapiddeclineintherenalfunctioninpatientswithgout
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Presence of tophi is associated with a rapid decline in the renal function in patients with gout

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