Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.

In diabetics, methylglyoxal (MG), a glucose-derived metabolite, plays a noxious role by inducing oxidative stress, which causes and exacerbates a series of complications including low-turnover osteoporosis. In the present study, while MG treatment of mouse bone marrow stroma-derived ST2 cells rapidl...

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Autores principales: Kiyoshi Mori, Riko Kitazawa, Takeshi Kondo, Michiko Mori, Yasuhiro Hamada, Michiru Nishida, Yasuhiro Minami, Ryuma Haraguchi, Yutaka Takahashi, Sohei Kitazawa
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/a9bfbcff677140e7a88001f5703c99f3
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