CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability is driven by cyclin D1 deficiency induced by SMARC...
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Nature Portfolio
2019
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oai:doaj.org-article:a9bfc57c02f44dfc91dacd68ff8a6a662021-12-02T14:38:45ZCDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary10.1038/s41467-018-06958-92041-1723https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a662019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06958-9https://doaj.org/toc/2041-1723Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability is driven by cyclin D1 deficiency induced by SMARCA4 loss.Yibo XueBrian MeehanElizabeth MacdonaldSriram VennetiXue Qing D. WangLeora WitkowskiPetar JelinicTim KongDaniel MartinezGeneviève MorinMichelle FirlitAtefeh AbediniRadia M. JohnsonRegina CencicJay PatibandlaHongbo ChenAndreas I. PapadakisAurelie AugusteIris de RinkRon M. KerkhovenNicholas BertosWalter H. GotliebBlaise A. ClarkeAlexandra LearyMichael WitcherMarie-Christine GuiotJerry PelletierJosée DostieMorag ParkAlexander R. JudkinsRalf HassDouglas A. LevineJanusz RakBarbara VanderhydenWilliam D. FoulkesSidong HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yibo Xue Brian Meehan Elizabeth Macdonald Sriram Venneti Xue Qing D. Wang Leora Witkowski Petar Jelinic Tim Kong Daniel Martinez Geneviève Morin Michelle Firlit Atefeh Abedini Radia M. Johnson Regina Cencic Jay Patibandla Hongbo Chen Andreas I. Papadakis Aurelie Auguste Iris de Rink Ron M. Kerkhoven Nicholas Bertos Walter H. Gotlieb Blaise A. Clarke Alexandra Leary Michael Witcher Marie-Christine Guiot Jerry Pelletier Josée Dostie Morag Park Alexander R. Judkins Ralf Hass Douglas A. Levine Janusz Rak Barbara Vanderhyden William D. Foulkes Sidong Huang CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| description |
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability is driven by cyclin D1 deficiency induced by SMARCA4 loss. |
| format |
article |
| author |
Yibo Xue Brian Meehan Elizabeth Macdonald Sriram Venneti Xue Qing D. Wang Leora Witkowski Petar Jelinic Tim Kong Daniel Martinez Geneviève Morin Michelle Firlit Atefeh Abedini Radia M. Johnson Regina Cencic Jay Patibandla Hongbo Chen Andreas I. Papadakis Aurelie Auguste Iris de Rink Ron M. Kerkhoven Nicholas Bertos Walter H. Gotlieb Blaise A. Clarke Alexandra Leary Michael Witcher Marie-Christine Guiot Jerry Pelletier Josée Dostie Morag Park Alexander R. Judkins Ralf Hass Douglas A. Levine Janusz Rak Barbara Vanderhyden William D. Foulkes Sidong Huang |
| author_facet |
Yibo Xue Brian Meehan Elizabeth Macdonald Sriram Venneti Xue Qing D. Wang Leora Witkowski Petar Jelinic Tim Kong Daniel Martinez Geneviève Morin Michelle Firlit Atefeh Abedini Radia M. Johnson Regina Cencic Jay Patibandla Hongbo Chen Andreas I. Papadakis Aurelie Auguste Iris de Rink Ron M. Kerkhoven Nicholas Bertos Walter H. Gotlieb Blaise A. Clarke Alexandra Leary Michael Witcher Marie-Christine Guiot Jerry Pelletier Josée Dostie Morag Park Alexander R. Judkins Ralf Hass Douglas A. Levine Janusz Rak Barbara Vanderhyden William D. Foulkes Sidong Huang |
| author_sort |
Yibo Xue |
| title |
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| title_short |
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| title_full |
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| title_fullStr |
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| title_full_unstemmed |
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| title_sort |
cdk4/6 inhibitors target smarca4-determined cyclin d1 deficiency in hypercalcemic small cell carcinoma of the ovary |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66 |
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