The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya

Introduction: In mechanically ventilated patients, ventilator-associated pneumonia (VAP) is a major cause of prolonged hospitalization with increased morbidity and mortality. There is a lack of studies on the relationship between bacterial colonization of the ventilator circuit (VC) and VAP. This st...

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Autores principales:	Asma Elkammoshi, Abir Ben Ashur, Hamida El Magrahi, Aya Abdulatif, Malak Almarouq
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2021
Materias:	ventilator circuit bacterial colonization antibiotic resistance intensive care unit Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a9c463db12ec41b4890af71a4c74470e
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spelling	oai:doaj.org-article:a9c463db12ec41b4890af71a4c74470e2021-12-02T15:37:21ZThe role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya10.5281/zenodo.46827402695-5075https://doaj.org/article/a9c463db12ec41b4890af71a4c74470e2021-04-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4682740https://doaj.org/toc/2695-5075Introduction: In mechanically ventilated patients, ventilator-associated pneumonia (VAP) is a major cause of prolonged hospitalization with increased morbidity and mortality. There is a lack of studies on the relationship between bacterial colonization of the ventilator circuit (VC) and VAP. This study aimed to investigate the role of bacterial colonization of VC in the development of VAP and identify antibiotic susceptibility trends for isolated strains. Methods: A prospective study of the bacterial culture has been performed between February 2021 to March 2021 on a total of 100 mechanically ventilated patients, (n =50) samples have been obtained from patient's lower respiratory tract (LRT) and (n =50) were taken from mechanical ventilator equipment VC. Paired samples of bacteria isolated from VC and LRT, where VC was colonized before LRT. Results: A total of 58 samples were cultured positively, while 42 specimens showed negative bacterial growth. However, there was no substantial difference in comparing between the bacterial colonization of the ventilator system and the patient samples. Most isolated organisms were gram-negative bacteria which were found in the ventilator circuit with 26 (68.4%), and 14 (70%) in patient’s LRT. Gram-positive was detected in 12 (31.6%) and 6 (30%) of the ventilator circuit, and patient's LRT, respectively. The predominant bacterial type was Acinetobacter baumannii organism at the VC with 10 (26.3%) and LRT at 4 (20%) followed by Klebsiella pneumoniae (8 (21.1%) in VC and 4 (20%) in LRT). Moreover, A. baumannii showed a full resistance to amoxicillin and the first generation of cephalosporins, while the other bacterial types were resistant to the most antibiotics used in this research. Conclusions: Bacterial colonization of ventilator circuit VC is a significant cause of VAP development in mechanically ventilated patients. Preventive strategies for the early detection and decontamination of contaminated VC can play a crucial role in ventilator-associated pneumonia prevention.Asma ElkammoshiAbir Ben AshurHamida El MagrahiAya AbdulatifMalak AlmarouqEmergency Department of Hospital San Pedro (Logroño, Spain)articleventilator circuitbacterial colonizationantibiotic resistanceintensive care unitMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 2, Pp 109-114 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ventilator circuit bacterial colonization antibiotic resistance intensive care unit Medicine (General) R5-920
spellingShingle	ventilator circuit bacterial colonization antibiotic resistance intensive care unit Medicine (General) R5-920 Asma Elkammoshi Abir Ben Ashur Hamida El Magrahi Aya Abdulatif Malak Almarouq The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
description	Introduction: In mechanically ventilated patients, ventilator-associated pneumonia (VAP) is a major cause of prolonged hospitalization with increased morbidity and mortality. There is a lack of studies on the relationship between bacterial colonization of the ventilator circuit (VC) and VAP. This study aimed to investigate the role of bacterial colonization of VC in the development of VAP and identify antibiotic susceptibility trends for isolated strains. Methods: A prospective study of the bacterial culture has been performed between February 2021 to March 2021 on a total of 100 mechanically ventilated patients, (n =50) samples have been obtained from patient's lower respiratory tract (LRT) and (n =50) were taken from mechanical ventilator equipment VC. Paired samples of bacteria isolated from VC and LRT, where VC was colonized before LRT. Results: A total of 58 samples were cultured positively, while 42 specimens showed negative bacterial growth. However, there was no substantial difference in comparing between the bacterial colonization of the ventilator system and the patient samples. Most isolated organisms were gram-negative bacteria which were found in the ventilator circuit with 26 (68.4%), and 14 (70%) in patient’s LRT. Gram-positive was detected in 12 (31.6%) and 6 (30%) of the ventilator circuit, and patient's LRT, respectively. The predominant bacterial type was Acinetobacter baumannii organism at the VC with 10 (26.3%) and LRT at 4 (20%) followed by Klebsiella pneumoniae (8 (21.1%) in VC and 4 (20%) in LRT). Moreover, A. baumannii showed a full resistance to amoxicillin and the first generation of cephalosporins, while the other bacterial types were resistant to the most antibiotics used in this research. Conclusions: Bacterial colonization of ventilator circuit VC is a significant cause of VAP development in mechanically ventilated patients. Preventive strategies for the early detection and decontamination of contaminated VC can play a crucial role in ventilator-associated pneumonia prevention.
format	article
author	Asma Elkammoshi Abir Ben Ashur Hamida El Magrahi Aya Abdulatif Malak Almarouq
author_facet	Asma Elkammoshi Abir Ben Ashur Hamida El Magrahi Aya Abdulatif Malak Almarouq
author_sort	Asma Elkammoshi
title	The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
title_short	The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
title_full	The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
title_fullStr	The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
title_full_unstemmed	The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya
title_sort	role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in icu of medical center hospital in tripoli, libya
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2021
url	https://doaj.org/article/a9c463db12ec41b4890af71a4c74470e
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The role of bacterial colonization of ventilator circuit in development of ventilator associated pneumonia in ICU of Medical Center Hospital in Tripoli, Libya

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