The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Acetaminophen-induced liver injury is one of the most common causes of liver failure and has to be treated within hours of the overdose. Here Barbier-Torres et al. show that targeting MCJ, a mitochondrial negative regulator, even 24 h after the overdose protects liver from acetaminophen-induced dama...

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Autores principales: Lucía Barbier-Torres, Paula Iruzubieta, David Fernández-Ramos, Teresa C. Delgado, Daniel Taibo, Virginia Guitiérrez-de-Juan, Marta Varela-Rey, Mikel Azkargorta, Nicolas Navasa, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Jorge Simon, Fernando Lopitz-Otsoa, Sofia Lachiondo-Ortega, Javier Crespo, Steven Masson, Misti Vanette McCain, Erica Villa, Helen Reeves, Felix Elortza, Maria Isabel Lucena, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Raúl J. Andrade, Shelly C. Lu, José M. Mato, Juan Anguita, Mercedes Rincón, María Luz Martínez-Chantar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a9c4f7b07bb74956911d961a97c3a9d5
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spelling oai:doaj.org-article:a9c4f7b07bb74956911d961a97c3a9d52021-12-02T14:42:51ZThe mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury10.1038/s41467-017-01970-x2041-1723https://doaj.org/article/a9c4f7b07bb74956911d961a97c3a9d52017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01970-xhttps://doaj.org/toc/2041-1723Acetaminophen-induced liver injury is one of the most common causes of liver failure and has to be treated within hours of the overdose. Here Barbier-Torres et al. show that targeting MCJ, a mitochondrial negative regulator, even 24 h after the overdose protects liver from acetaminophen-induced damage.Lucía Barbier-TorresPaula IruzubietaDavid Fernández-RamosTeresa C. DelgadoDaniel TaiboVirginia Guitiérrez-de-JuanMarta Varela-ReyMikel AzkargortaNicolas NavasaPablo Fernández-TussyImanol Zubiete-FrancoJorge SimonFernando Lopitz-OtsoaSofia Lachiondo-OrtegaJavier CrespoSteven MassonMisti Vanette McCainErica VillaHelen ReevesFelix ElortzaMaria Isabel LucenaMaria Isabel Hernández-AlvarezAntonio ZorzanoRaúl J. AndradeShelly C. LuJosé M. MatoJuan AnguitaMercedes RincónMaría Luz Martínez-ChantarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lucía Barbier-Torres
Paula Iruzubieta
David Fernández-Ramos
Teresa C. Delgado
Daniel Taibo
Virginia Guitiérrez-de-Juan
Marta Varela-Rey
Mikel Azkargorta
Nicolas Navasa
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Jorge Simon
Fernando Lopitz-Otsoa
Sofia Lachiondo-Ortega
Javier Crespo
Steven Masson
Misti Vanette McCain
Erica Villa
Helen Reeves
Felix Elortza
Maria Isabel Lucena
Maria Isabel Hernández-Alvarez
Antonio Zorzano
Raúl J. Andrade
Shelly C. Lu
José M. Mato
Juan Anguita
Mercedes Rincón
María Luz Martínez-Chantar
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
description Acetaminophen-induced liver injury is one of the most common causes of liver failure and has to be treated within hours of the overdose. Here Barbier-Torres et al. show that targeting MCJ, a mitochondrial negative regulator, even 24 h after the overdose protects liver from acetaminophen-induced damage.
format article
author Lucía Barbier-Torres
Paula Iruzubieta
David Fernández-Ramos
Teresa C. Delgado
Daniel Taibo
Virginia Guitiérrez-de-Juan
Marta Varela-Rey
Mikel Azkargorta
Nicolas Navasa
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Jorge Simon
Fernando Lopitz-Otsoa
Sofia Lachiondo-Ortega
Javier Crespo
Steven Masson
Misti Vanette McCain
Erica Villa
Helen Reeves
Felix Elortza
Maria Isabel Lucena
Maria Isabel Hernández-Alvarez
Antonio Zorzano
Raúl J. Andrade
Shelly C. Lu
José M. Mato
Juan Anguita
Mercedes Rincón
María Luz Martínez-Chantar
author_facet Lucía Barbier-Torres
Paula Iruzubieta
David Fernández-Ramos
Teresa C. Delgado
Daniel Taibo
Virginia Guitiérrez-de-Juan
Marta Varela-Rey
Mikel Azkargorta
Nicolas Navasa
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Jorge Simon
Fernando Lopitz-Otsoa
Sofia Lachiondo-Ortega
Javier Crespo
Steven Masson
Misti Vanette McCain
Erica Villa
Helen Reeves
Felix Elortza
Maria Isabel Lucena
Maria Isabel Hernández-Alvarez
Antonio Zorzano
Raúl J. Andrade
Shelly C. Lu
José M. Mato
Juan Anguita
Mercedes Rincón
María Luz Martínez-Chantar
author_sort Lucía Barbier-Torres
title The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
title_short The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
title_full The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
title_fullStr The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
title_full_unstemmed The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
title_sort mitochondrial negative regulator mcj is a therapeutic target for acetaminophen-induced liver injury
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a9c4f7b07bb74956911d961a97c3a9d5
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