Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

Abstract Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multic...

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Autores principales:	A. Ahnaou, D. Moechars, L. Raeymaekers, R. Biermans, N. V. Manyakov, A. Bottelbergs, C. Wintmolders, K. Van Kolen, T. Van De Casteele, J. A. Kemp, W. H. Drinkenburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9c5148746e4437dbedab4ea4cfaf87c
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spelling	oai:doaj.org-article:a9c5148746e4437dbedab4ea4cfaf87c2021-12-02T11:53:10ZEmergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology10.1038/s41598-017-13839-62045-2322https://doaj.org/article/a9c5148746e4437dbedab4ea4cfaf87c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13839-6https://doaj.org/toc/2045-2322Abstract Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multichannel EEG oscillations were used to compute (1) coherent activity between the prefrontal cortex (PFC) and hippocampus (HPC) CA1-CA3 networks; (2) phase-amplitude cross frequency coupling (PAC) between theta and gamma oscillations, which is instrumental in adequate cognitive functioning; (3) information processing as assessed by auditory evoked potentials and oscillations in the passive oddball mismatch negativity-like (MMN) paradigm. At the end, the density of tau aggregation and GABA parvalbumin (PV+) interneurons were quantified by immunohistochemistry. Early weakening of EEG theta oscillations and coherent activity were revealed between the PFC and HPC CA1 and drastic impairments in theta–gamma oscillations PAC from week 2 onwards, while PV+ interneurons count was not altered. Moreover, the tau pathology disrupted the MMN complex amplitude and evoked gamma oscillations to standard and deviant stimuli suggesting altered memory formation and recall. The induction of intracellular tau aggregation by tau seed injection results in early altered connectivity and strong theta–gamma oscillations uncoupling, which may be exploited as an early electrophysiological signature of dysfunctional neuronal networks.A. AhnaouD. MoecharsL. RaeymaekersR. BiermansN. V. ManyakovA. BottelbergsC. WintmoldersK. Van KolenT. Van De CasteeleJ. A. KempW. H. DrinkenburgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Ahnaou D. Moechars L. Raeymaekers R. Biermans N. V. Manyakov A. Bottelbergs C. Wintmolders K. Van Kolen T. Van De Casteele J. A. Kemp W. H. Drinkenburg Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
description	Abstract Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multichannel EEG oscillations were used to compute (1) coherent activity between the prefrontal cortex (PFC) and hippocampus (HPC) CA1-CA3 networks; (2) phase-amplitude cross frequency coupling (PAC) between theta and gamma oscillations, which is instrumental in adequate cognitive functioning; (3) information processing as assessed by auditory evoked potentials and oscillations in the passive oddball mismatch negativity-like (MMN) paradigm. At the end, the density of tau aggregation and GABA parvalbumin (PV+) interneurons were quantified by immunohistochemistry. Early weakening of EEG theta oscillations and coherent activity were revealed between the PFC and HPC CA1 and drastic impairments in theta–gamma oscillations PAC from week 2 onwards, while PV+ interneurons count was not altered. Moreover, the tau pathology disrupted the MMN complex amplitude and evoked gamma oscillations to standard and deviant stimuli suggesting altered memory formation and recall. The induction of intracellular tau aggregation by tau seed injection results in early altered connectivity and strong theta–gamma oscillations uncoupling, which may be exploited as an early electrophysiological signature of dysfunctional neuronal networks.
format	article
author	A. Ahnaou D. Moechars L. Raeymaekers R. Biermans N. V. Manyakov A. Bottelbergs C. Wintmolders K. Van Kolen T. Van De Casteele J. A. Kemp W. H. Drinkenburg
author_facet	A. Ahnaou D. Moechars L. Raeymaekers R. Biermans N. V. Manyakov A. Bottelbergs C. Wintmolders K. Van Kolen T. Van De Casteele J. A. Kemp W. H. Drinkenburg
author_sort	A. Ahnaou
title	Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
title_short	Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
title_full	Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
title_fullStr	Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
title_full_unstemmed	Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology
title_sort	emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of alzheimer’s disease pathology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9c5148746e4437dbedab4ea4cfaf87c
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Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

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