Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study

Objectives Patients with peripheral artery disease (PAD) are reported to have a poorer prognosis than those without PAD. PAD is sometimes found at dialysis initiation, but its influence on the prognosis in these patients has not been investigated. We aimed to compare the mortality rate between patie...

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Autores principales:	Shoichi Maruyama, Hikaru Morooka, Akihito Tanaka, Daijo Inaguma
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2020
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/a9c6671ac4594de386454ebce32eb021
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spelling	oai:doaj.org-article:a9c6671ac4594de386454ebce32eb0212021-11-18T06:30:07ZPeripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study10.1136/bmjopen-2020-0423152044-6055https://doaj.org/article/a9c6671ac4594de386454ebce32eb0212020-12-01T00:00:00Zhttps://bmjopen.bmj.com/content/10/12/e042315.fullhttps://doaj.org/toc/2044-6055Objectives Patients with peripheral artery disease (PAD) are reported to have a poorer prognosis than those without PAD. PAD is sometimes found at dialysis initiation, but its influence on the prognosis in these patients has not been investigated. We aimed to compare the mortality rate between patients with PAD at the time of dialysis initiation and those without PAD.Design We undertook an observational prospective multicenter study of patients starting dialysis treatment. Data were collected on patients’ sex, age, presence of PAD, medication, medical history and clinical and laboratory data.Setting Seventeen centers participated in the Aichi Cohort Study of Prognosis in Patients Newly Initiated into Dialysis.Participants A total of 1524 patients with chronic kidney disease started dialysis from October 2011 to September 2013. The patients were followed-up until March 2015. During this time, there were two patients who lost the follow-up.Primary and secondary outcome measures The primary outcome was defined as all-cause mortality. The secondary outcomes were defined as each cause of mortality.Results This study included 1030 men and 492 women with a mean age of 67.50±13.10 years. Of these, 71 had PAD and 1451 did not have PAD. After a median follow-up of 814.5 days, 33.80% of the former group and 17.00% of the latter group had died in March 2015 (p=0.001). After adjusting for confounding factors, PAD at dialysis initiation remained an independent risk factor for mortality (p<0.01).Conclusions Patients with PAD at the time of dialysis initiation had a poorer prognosis than patients without PAD. Therefore, the presence of PAD in patients starting dialysis should be considered for their monitoring and follow-up.Shoichi MaruyamaHikaru MorookaAkihito TanakaDaijo InagumaBMJ Publishing GrouparticleMedicineRENBMJ Open, Vol 10, Iss 12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Shoichi Maruyama Hikaru Morooka Akihito Tanaka Daijo Inaguma Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
description	Objectives Patients with peripheral artery disease (PAD) are reported to have a poorer prognosis than those without PAD. PAD is sometimes found at dialysis initiation, but its influence on the prognosis in these patients has not been investigated. We aimed to compare the mortality rate between patients with PAD at the time of dialysis initiation and those without PAD.Design We undertook an observational prospective multicenter study of patients starting dialysis treatment. Data were collected on patients’ sex, age, presence of PAD, medication, medical history and clinical and laboratory data.Setting Seventeen centers participated in the Aichi Cohort Study of Prognosis in Patients Newly Initiated into Dialysis.Participants A total of 1524 patients with chronic kidney disease started dialysis from October 2011 to September 2013. The patients were followed-up until March 2015. During this time, there were two patients who lost the follow-up.Primary and secondary outcome measures The primary outcome was defined as all-cause mortality. The secondary outcomes were defined as each cause of mortality.Results This study included 1030 men and 492 women with a mean age of 67.50±13.10 years. Of these, 71 had PAD and 1451 did not have PAD. After a median follow-up of 814.5 days, 33.80% of the former group and 17.00% of the latter group had died in March 2015 (p=0.001). After adjusting for confounding factors, PAD at dialysis initiation remained an independent risk factor for mortality (p<0.01).Conclusions Patients with PAD at the time of dialysis initiation had a poorer prognosis than patients without PAD. Therefore, the presence of PAD in patients starting dialysis should be considered for their monitoring and follow-up.
format	article
author	Shoichi Maruyama Hikaru Morooka Akihito Tanaka Daijo Inaguma
author_facet	Shoichi Maruyama Hikaru Morooka Akihito Tanaka Daijo Inaguma
author_sort	Shoichi Maruyama
title	Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
title_short	Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
title_full	Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
title_fullStr	Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
title_full_unstemmed	Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
title_sort	peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study
publisher	BMJ Publishing Group
publishDate	2020
url	https://doaj.org/article/a9c6671ac4594de386454ebce32eb021
work_keys_str_mv	AT shoichimaruyama peripheralarterydiseaseatthetimeofdialysisinitiationandmortalityaprospectiveobservationalmulticenterstudy AT hikarumorooka peripheralarterydiseaseatthetimeofdialysisinitiationandmortalityaprospectiveobservationalmulticenterstudy AT akihitotanaka peripheralarterydiseaseatthetimeofdialysisinitiationandmortalityaprospectiveobservationalmulticenterstudy AT daijoinaguma peripheralarterydiseaseatthetimeofdialysisinitiationandmortalityaprospectiveobservationalmulticenterstudy
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Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study

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