Molecular evidence of functional progesterone withdrawal in human myometrium

How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.

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Autores principales:	Lubna Nadeem, Oksana Shynlova, Elzbieta Matysiak-Zablocki, Sam Mesiano, Xuesen Dong, Stephen Lye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9cbb860df8546a38946568c449db560
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spelling	oai:doaj.org-article:a9cbb860df8546a38946568c449db5602021-12-02T16:56:45ZMolecular evidence of functional progesterone withdrawal in human myometrium10.1038/ncomms115652041-1723https://doaj.org/article/a9cbb860df8546a38946568c449db5602016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11565https://doaj.org/toc/2041-1723How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.Lubna NadeemOksana ShynlovaElzbieta Matysiak-ZablockiSam MesianoXuesen DongStephen LyeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye Molecular evidence of functional progesterone withdrawal in human myometrium
description	How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.
format	article
author	Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye
author_facet	Lubna Nadeem Oksana Shynlova Elzbieta Matysiak-Zablocki Sam Mesiano Xuesen Dong Stephen Lye
author_sort	Lubna Nadeem
title	Molecular evidence of functional progesterone withdrawal in human myometrium
title_short	Molecular evidence of functional progesterone withdrawal in human myometrium
title_full	Molecular evidence of functional progesterone withdrawal in human myometrium
title_fullStr	Molecular evidence of functional progesterone withdrawal in human myometrium
title_full_unstemmed	Molecular evidence of functional progesterone withdrawal in human myometrium
title_sort	molecular evidence of functional progesterone withdrawal in human myometrium
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a9cbb860df8546a38946568c449db560
work_keys_str_mv	AT lubnanadeem molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium AT oksanashynlova molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium AT elzbietamatysiakzablocki molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium AT sammesiano molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium AT xuesendong molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium AT stephenlye molecularevidenceoffunctionalprogesteronewithdrawalinhumanmyometrium
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Molecular evidence of functional progesterone withdrawal in human myometrium

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