A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation

Gang Tan,1,2,* Xin Huang,1,3,* Ying Zhang,1 An-Hua Wu,2 Yu-Lin Zhong,1 Kai Wu,2 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi, 2Departmen...

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Autores principales:	Tan G, Huang X, Zhang Y, Wu AH, Zhong YL, Wu K, Zhou FQ, Shao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	ALFF congenital comitant strabismus resting state spontaneous activity anxiety and depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a9cf20be48cd4a569a52a3d0254184a5
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spelling	oai:doaj.org-article:a9cf20be48cd4a569a52a3d0254184a52021-12-02T02:56:00ZA functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation1178-2021https://doaj.org/article/a9cf20be48cd4a569a52a3d0254184a52016-05-01T00:00:00Zhttps://www.dovepress.com/a-functional-mri-study-of-altered-spontaneous-brain-activity-pattern-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gang Tan,1,2,* Xin Huang,1,3,* Ying Zhang,1 An-Hua Wu,2 Yu-Lin Zhong,1 Kai Wu,2 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, 3Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 4Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to investigate local features of spontaneous brain activity in patients with congenital comitant strabismus and clarify their relationship with emotional and psychosocial problems. Methods: A total of 20 patients with congenital comitant strabismus (ten males and ten females), and 20 healthy controls (ten males and ten females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. Congenital comitant strabismus patients were distinguished from healthy controls by receiver operating characteristic curve. Correlation analysis was performed to explore the relationships between the observed mean ALFF signal values of the different areas and the Chinese version of the Hospital Anxiety and Depression Scale. Results: Compared with healthy controls, patients with congenital comitant strabismus had significantly lower ALFF in the bilateral medialfrontal gyrus and higher values in the bilateral cerebellum posterior lobe and left angular gyrus. In the congenital comitant strabismus group, the Hospital Anxiety and Depression Scale-depression score showed a negative correlation with the ALFF signal values of the bilateral medial frontal gyrus (r=-0.550, P=0.012) and a negative correlation was noted between the mean ALFF signal values of the left angular gyrus and strabismus duration (r=-0.515, P=0.020). Conclusion: Congenital comitant strabismus mainly involves dysfunction in the bilateral medial frontal gyrus, bilateral cerebellum posterior lobe, and left angular gyrus, which may reflect the underlying pathologic mechanism of congenital strabismus. Keywords: ALFF, congenital comitant strabismus, resting state, spontaneous activity, anxiety and depressionTan GHuang XZhang YWu AHZhong YLWu KZhou FQShao YDove Medical PressarticleALFFcongenital comitant strabismusresting statespontaneous activityanxiety and depressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1243-1250 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALFF congenital comitant strabismus resting state spontaneous activity anxiety and depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ALFF congenital comitant strabismus resting state spontaneous activity anxiety and depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tan G Huang X Zhang Y Wu AH Zhong YL Wu K Zhou FQ Shao Y A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
description	Gang Tan,1,2,* Xin Huang,1,3,* Ying Zhang,1 An-Hua Wu,2 Yu-Lin Zhong,1 Kai Wu,2 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, 3Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 4Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to investigate local features of spontaneous brain activity in patients with congenital comitant strabismus and clarify their relationship with emotional and psychosocial problems. Methods: A total of 20 patients with congenital comitant strabismus (ten males and ten females), and 20 healthy controls (ten males and ten females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. Congenital comitant strabismus patients were distinguished from healthy controls by receiver operating characteristic curve. Correlation analysis was performed to explore the relationships between the observed mean ALFF signal values of the different areas and the Chinese version of the Hospital Anxiety and Depression Scale. Results: Compared with healthy controls, patients with congenital comitant strabismus had significantly lower ALFF in the bilateral medialfrontal gyrus and higher values in the bilateral cerebellum posterior lobe and left angular gyrus. In the congenital comitant strabismus group, the Hospital Anxiety and Depression Scale-depression score showed a negative correlation with the ALFF signal values of the bilateral medial frontal gyrus (r=-0.550, P=0.012) and a negative correlation was noted between the mean ALFF signal values of the left angular gyrus and strabismus duration (r=-0.515, P=0.020). Conclusion: Congenital comitant strabismus mainly involves dysfunction in the bilateral medial frontal gyrus, bilateral cerebellum posterior lobe, and left angular gyrus, which may reflect the underlying pathologic mechanism of congenital strabismus. Keywords: ALFF, congenital comitant strabismus, resting state, spontaneous activity, anxiety and depression
format	article
author	Tan G Huang X Zhang Y Wu AH Zhong YL Wu K Zhou FQ Shao Y
author_facet	Tan G Huang X Zhang Y Wu AH Zhong YL Wu K Zhou FQ Shao Y
author_sort	Tan G
title	A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
title_short	A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
title_full	A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
title_fullStr	A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
title_full_unstemmed	A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
title_sort	functional mri study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a9cf20be48cd4a569a52a3d0254184a5
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A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation

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