Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.

<h4>Background</h4>AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findin...

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Autores principales:	Hairu Wang, Ming Wu, Weiguang Zhu, Jin Shen, Xiaoming Shi, Jie Yang, Qihui Zhao, Chuan Ni, Yaochu Xu, Hongbing Shen, Chong Shen, Harvest F Gu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9d14c3397d04b08ac55f48c42937ba4
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spelling	oai:doaj.org-article:a9d14c3397d04b08ac55f48c42937ba42021-11-18T07:02:27ZEvaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.1932-620310.1371/journal.pone.0013851https://doaj.org/article/a9d14c3397d04b08ac55f48c42937ba42010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21079816/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.<h4>Methodology/principal findings</h4>In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.<h4>Conclusions</h4>The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.Hairu WangMing WuWeiguang ZhuJin ShenXiaoming ShiJie YangQihui ZhaoChuan NiYaochu XuHongbing ShenChong ShenHarvest F GuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13851 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hairu Wang Ming Wu Weiguang Zhu Jin Shen Xiaoming Shi Jie Yang Qihui Zhao Chuan Ni Yaochu Xu Hongbing Shen Chong Shen Harvest F Gu Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
description	<h4>Background</h4>AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.<h4>Methodology/principal findings</h4>In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.<h4>Conclusions</h4>The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.
format	article
author	Hairu Wang Ming Wu Weiguang Zhu Jin Shen Xiaoming Shi Jie Yang Qihui Zhao Chuan Ni Yaochu Xu Hongbing Shen Chong Shen Harvest F Gu
author_facet	Hairu Wang Ming Wu Weiguang Zhu Jin Shen Xiaoming Shi Jie Yang Qihui Zhao Chuan Ni Yaochu Xu Hongbing Shen Chong Shen Harvest F Gu
author_sort	Hairu Wang
title	Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
title_short	Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
title_full	Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
title_fullStr	Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
title_full_unstemmed	Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
title_sort	evaluation of the association between the ac3 genetic polymorphisms and obesity in a chinese han population.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/a9d14c3397d04b08ac55f48c42937ba4
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Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.

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