Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation

Aberrant lipid metabolism, especially dyslipidemia, has gained attention since it is closely related to various health disorders. Evidence that wild bitter melon (WBM), a natural herbal food, plays a regulatory function in lipid synthesis and accumulation has accumulated. In our study, we isolated 3...

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Autores principales:	Semon Wu, Cheng Huang, You-Ren Chen, Hsiu-Chen Huang, Wen-Cheng Huang, Yu-Heng Lai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Momordica charantia Dyslipidemia Hepatic lipid accumulation PPAR Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/a9d64cd17b8040eabac03e7d2396d143
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spelling	oai:doaj.org-article:a9d64cd17b8040eabac03e7d2396d1432021-11-18T04:46:21ZMomordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation1756-464610.1016/j.jff.2021.104857https://doaj.org/article/a9d64cd17b8040eabac03e7d2396d1432021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005065https://doaj.org/toc/1756-4646Aberrant lipid metabolism, especially dyslipidemia, has gained attention since it is closely related to various health disorders. Evidence that wild bitter melon (WBM), a natural herbal food, plays a regulatory function in lipid synthesis and accumulation has accumulated. In our study, we isolated 3β,7β,25-trihydroxycucurbita-5,23-dien-19-al (TCD) fraction of WBM leaf extract and established a dyslipidemia model to validate the effects of TCD on human adipocytes and zebrafish. After being treated with WBM, hypertrophy was inhibited in adipocytes, and lipid accumulation was diminished in zebrafish livers. In addition, lipogenic markers, including peroxisome-proliferator-activated receptor α (PPARα) and fatty acid synthase (FASN), significantly decreased when zebrafish were given WBM extract after they were given a high-fat diet. These findings explored the role of WBM in lipid metabolism and provided new insights into the pharmaceutic application of TCD in dyslipidemia.Semon WuCheng HuangYou-Ren ChenHsiu-Chen HuangWen-Cheng HuangYu-Heng LaiElsevierarticleMomordica charantiaDyslipidemiaHepatic lipid accumulationPPARNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104857- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Momordica charantia Dyslipidemia Hepatic lipid accumulation PPAR Nutrition. Foods and food supply TX341-641
spellingShingle	Momordica charantia Dyslipidemia Hepatic lipid accumulation PPAR Nutrition. Foods and food supply TX341-641 Semon Wu Cheng Huang You-Ren Chen Hsiu-Chen Huang Wen-Cheng Huang Yu-Heng Lai Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
description	Aberrant lipid metabolism, especially dyslipidemia, has gained attention since it is closely related to various health disorders. Evidence that wild bitter melon (WBM), a natural herbal food, plays a regulatory function in lipid synthesis and accumulation has accumulated. In our study, we isolated 3β,7β,25-trihydroxycucurbita-5,23-dien-19-al (TCD) fraction of WBM leaf extract and established a dyslipidemia model to validate the effects of TCD on human adipocytes and zebrafish. After being treated with WBM, hypertrophy was inhibited in adipocytes, and lipid accumulation was diminished in zebrafish livers. In addition, lipogenic markers, including peroxisome-proliferator-activated receptor α (PPARα) and fatty acid synthase (FASN), significantly decreased when zebrafish were given WBM extract after they were given a high-fat diet. These findings explored the role of WBM in lipid metabolism and provided new insights into the pharmaceutic application of TCD in dyslipidemia.
format	article
author	Semon Wu Cheng Huang You-Ren Chen Hsiu-Chen Huang Wen-Cheng Huang Yu-Heng Lai
author_facet	Semon Wu Cheng Huang You-Ren Chen Hsiu-Chen Huang Wen-Cheng Huang Yu-Heng Lai
author_sort	Semon Wu
title	Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
title_short	Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
title_full	Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
title_fullStr	Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
title_full_unstemmed	Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
title_sort	momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a9d64cd17b8040eabac03e7d2396d143
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Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation

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