The dynamic dimer structure of the chaperone Trigger Factor

The bacterial chaperone Trigger Factor (TF) is a dynamic protein and its dimer structure is unknown. Here the authors present a protocol combining NMR, computational and biophysical methods for the structural characterization of large dynamic protein complexes and show that TF forms a symmetric head...

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Autores principales:	Leonor Morgado, Björn M. Burmann, Timothy Sharpe, Adam Mazur, Sebastian Hiller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9d9f19b2e0e4378a4b71003d428d801
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spelling	oai:doaj.org-article:a9d9f19b2e0e4378a4b71003d428d8012021-12-02T17:06:22ZThe dynamic dimer structure of the chaperone Trigger Factor10.1038/s41467-017-02196-72041-1723https://doaj.org/article/a9d9f19b2e0e4378a4b71003d428d8012017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02196-7https://doaj.org/toc/2041-1723The bacterial chaperone Trigger Factor (TF) is a dynamic protein and its dimer structure is unknown. Here the authors present a protocol combining NMR, computational and biophysical methods for the structural characterization of large dynamic protein complexes and show that TF forms a symmetric head-to-tail dimer.Leonor MorgadoBjörn M. BurmannTimothy SharpeAdam MazurSebastian HillerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonor Morgado Björn M. Burmann Timothy Sharpe Adam Mazur Sebastian Hiller The dynamic dimer structure of the chaperone Trigger Factor
description	The bacterial chaperone Trigger Factor (TF) is a dynamic protein and its dimer structure is unknown. Here the authors present a protocol combining NMR, computational and biophysical methods for the structural characterization of large dynamic protein complexes and show that TF forms a symmetric head-to-tail dimer.
format	article
author	Leonor Morgado Björn M. Burmann Timothy Sharpe Adam Mazur Sebastian Hiller
author_facet	Leonor Morgado Björn M. Burmann Timothy Sharpe Adam Mazur Sebastian Hiller
author_sort	Leonor Morgado
title	The dynamic dimer structure of the chaperone Trigger Factor
title_short	The dynamic dimer structure of the chaperone Trigger Factor
title_full	The dynamic dimer structure of the chaperone Trigger Factor
title_fullStr	The dynamic dimer structure of the chaperone Trigger Factor
title_full_unstemmed	The dynamic dimer structure of the chaperone Trigger Factor
title_sort	dynamic dimer structure of the chaperone trigger factor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9d9f19b2e0e4378a4b71003d428d801
work_keys_str_mv	AT leonormorgado thedynamicdimerstructureofthechaperonetriggerfactor AT bjornmburmann thedynamicdimerstructureofthechaperonetriggerfactor AT timothysharpe thedynamicdimerstructureofthechaperonetriggerfactor AT adammazur thedynamicdimerstructureofthechaperonetriggerfactor AT sebastianhiller thedynamicdimerstructureofthechaperonetriggerfactor AT leonormorgado dynamicdimerstructureofthechaperonetriggerfactor AT bjornmburmann dynamicdimerstructureofthechaperonetriggerfactor AT timothysharpe dynamicdimerstructureofthechaperonetriggerfactor AT adammazur dynamicdimerstructureofthechaperonetriggerfactor AT sebastianhiller dynamicdimerstructureofthechaperonetriggerfactor
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The dynamic dimer structure of the chaperone Trigger Factor

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