Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Although Hippo signaling restricts regeneration in many mammalian organs, the pharmaceutical tools available to modulate the pathway have been limited. Here, the authors report a small molecule that may inhibit a key element in the Hippo cascade and may activate regenerative responses in several mam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, A. J. Hudspeth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9dbde1730a749f6acae7a54edd1e572
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a9dbde1730a749f6acae7a54edd1e572
record_format	dspace
spelling	oai:doaj.org-article:a9dbde1730a749f6acae7a54edd1e5722021-12-02T15:49:48ZSmall-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues10.1038/s41467-021-23395-32041-1723https://doaj.org/article/a9dbde1730a749f6acae7a54edd1e5722021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23395-3https://doaj.org/toc/2041-1723Although Hippo signaling restricts regeneration in many mammalian organs, the pharmaceutical tools available to modulate the pathway have been limited. Here, the authors report a small molecule that may inhibit a key element in the Hippo cascade and may activate regenerative responses in several mammalian tissues.Nathaniel KastanKsenia GnedevaTheresa AlischAleksandra A. PetelskiDavid J. HugginsJeanne ChiaravalliAlla AharanovAvraham ShakkedEldad TzahorAaron NagielNeil SegilA. J. HudspethNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathaniel Kastan Ksenia Gnedeva Theresa Alisch Aleksandra A. Petelski David J. Huggins Jeanne Chiaravalli Alla Aharanov Avraham Shakked Eldad Tzahor Aaron Nagiel Neil Segil A. J. Hudspeth Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
description	Although Hippo signaling restricts regeneration in many mammalian organs, the pharmaceutical tools available to modulate the pathway have been limited. Here, the authors report a small molecule that may inhibit a key element in the Hippo cascade and may activate regenerative responses in several mammalian tissues.
format	article
author	Nathaniel Kastan Ksenia Gnedeva Theresa Alisch Aleksandra A. Petelski David J. Huggins Jeanne Chiaravalli Alla Aharanov Avraham Shakked Eldad Tzahor Aaron Nagiel Neil Segil A. J. Hudspeth
author_facet	Nathaniel Kastan Ksenia Gnedeva Theresa Alisch Aleksandra A. Petelski David J. Huggins Jeanne Chiaravalli Alla Aharanov Avraham Shakked Eldad Tzahor Aaron Nagiel Neil Segil A. J. Hudspeth
author_sort	Nathaniel Kastan
title	Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
title_short	Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
title_full	Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
title_fullStr	Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
title_full_unstemmed	Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
title_sort	small-molecule inhibition of lats kinases may promote yap-dependent proliferation in postmitotic mammalian tissues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a9dbde1730a749f6acae7a54edd1e572
work_keys_str_mv	AT nathanielkastan smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT kseniagnedeva smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT theresaalisch smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT aleksandraapetelski smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT davidjhuggins smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT jeannechiaravalli smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT allaaharanov smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT avrahamshakked smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT eldadtzahor smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT aaronnagiel smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT neilsegil smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues AT ajhudspeth smallmoleculeinhibitionoflatskinasesmaypromoteyapdependentproliferationinpostmitoticmammaliantissues
_version_	1718385709882015744

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Ejemplares similares