ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.

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Autores principales:	Xiaoyun Sun, Xixia Peng, Yuqin Cao, Yan Zhou, Yuhua Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9e1314be5cb408b847ffc95329b794a
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spelling	oai:doaj.org-article:a9e1314be5cb408b847ffc95329b794a2021-12-02T14:59:27ZADNP promotes neural differentiation by modulating Wnt/β-catenin signaling10.1038/s41467-020-16799-02041-1723https://doaj.org/article/a9e1314be5cb408b847ffc95329b794a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16799-0https://doaj.org/toc/2041-1723ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.Xiaoyun SunXixia PengYuqin CaoYan ZhouYuhua SunNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyun Sun Xixia Peng Yuqin Cao Yan Zhou Yuhua Sun ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
description	ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.
format	article
author	Xiaoyun Sun Xixia Peng Yuqin Cao Yan Zhou Yuhua Sun
author_facet	Xiaoyun Sun Xixia Peng Yuqin Cao Yan Zhou Yuhua Sun
author_sort	Xiaoyun Sun
title	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
title_short	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
title_full	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
title_fullStr	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
title_full_unstemmed	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
title_sort	adnp promotes neural differentiation by modulating wnt/β-catenin signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a9e1314be5cb408b847ffc95329b794a
work_keys_str_mv	AT xiaoyunsun adnppromotesneuraldifferentiationbymodulatingwntbcateninsignaling AT xixiapeng adnppromotesneuraldifferentiationbymodulatingwntbcateninsignaling AT yuqincao adnppromotesneuraldifferentiationbymodulatingwntbcateninsignaling AT yanzhou adnppromotesneuraldifferentiationbymodulatingwntbcateninsignaling AT yuhuasun adnppromotesneuraldifferentiationbymodulatingwntbcateninsignaling
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ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

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