Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus
The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins that target regions of the distal colon rich in sialo...
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Nature Portfolio
2017
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oai:doaj.org-article:a9e2f73219e849be977339d14d916fea2021-12-02T14:40:37ZUnravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus10.1038/s41467-017-02109-82041-1723https://doaj.org/article/a9e2f73219e849be977339d14d916fea2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02109-8https://doaj.org/toc/2041-1723The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins that target regions of the distal colon rich in sialomucins.C. David OwenLouise E. TailfordSerena MonacoTanja ŠuligojLaura VauxRomane LallementZahra KhedriHai YuKarine LecointeJohn WalshawSandra TriboloMarc HorrexAndrew BellXi ChenGary L. TaylorAjit VarkiJesus AnguloNathalie JugeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q C. David Owen Louise E. Tailford Serena Monaco Tanja Šuligoj Laura Vaux Romane Lallement Zahra Khedri Hai Yu Karine Lecointe John Walshaw Sandra Tribolo Marc Horrex Andrew Bell Xi Chen Gary L. Taylor Ajit Varki Jesus Angulo Nathalie Juge Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| description |
The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins that target regions of the distal colon rich in sialomucins. |
| format |
article |
| author |
C. David Owen Louise E. Tailford Serena Monaco Tanja Šuligoj Laura Vaux Romane Lallement Zahra Khedri Hai Yu Karine Lecointe John Walshaw Sandra Tribolo Marc Horrex Andrew Bell Xi Chen Gary L. Taylor Ajit Varki Jesus Angulo Nathalie Juge |
| author_facet |
C. David Owen Louise E. Tailford Serena Monaco Tanja Šuligoj Laura Vaux Romane Lallement Zahra Khedri Hai Yu Karine Lecointe John Walshaw Sandra Tribolo Marc Horrex Andrew Bell Xi Chen Gary L. Taylor Ajit Varki Jesus Angulo Nathalie Juge |
| author_sort |
C. David Owen |
| title |
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| title_short |
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| title_full |
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| title_fullStr |
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| title_full_unstemmed |
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus |
| title_sort |
unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont ruminococcus gnavus |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a9e2f73219e849be977339d14d916fea |
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| _version_ |
1718390256966828032 |