Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications

Summary The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click...

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Autores principales:	Nazir Ahmad, Hussein A. Younus, Adeel H. Chughtai, Kristof Van Hecke, Muhammad Danish, Zhang Gaoke, Francis Verpoort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9e3720db3014012b890c53d0e8ba073
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spelling	oai:doaj.org-article:a9e3720db3014012b890c53d0e8ba0732021-12-02T16:06:39ZDevelopment of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications10.1038/s41598-017-00733-42045-2322https://doaj.org/article/a9e3720db3014012b890c53d0e8ba0732017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00733-4https://doaj.org/toc/2045-2322Summary The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37 °C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding.Nazir AhmadHussein A. YounusAdeel H. ChughtaiKristof Van HeckeMuhammad DanishZhang GaokeFrancis VerpoortNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nazir Ahmad Hussein A. Younus Adeel H. Chughtai Kristof Van Hecke Muhammad Danish Zhang Gaoke Francis Verpoort Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
description	Summary The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37 °C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding.
format	article
author	Nazir Ahmad Hussein A. Younus Adeel H. Chughtai Kristof Van Hecke Muhammad Danish Zhang Gaoke Francis Verpoort
author_facet	Nazir Ahmad Hussein A. Younus Adeel H. Chughtai Kristof Van Hecke Muhammad Danish Zhang Gaoke Francis Verpoort
author_sort	Nazir Ahmad
title	Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
title_short	Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
title_full	Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
title_fullStr	Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
title_full_unstemmed	Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
title_sort	development of mixed metal metal-organic polyhedra networks, colloids, and mofs and their pharmacokinetic applications
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9e3720db3014012b890c53d0e8ba073
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Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications

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