Computational design of chemogenetic and optogenetic split proteins

Designing split protein approaches is time consuming and often results in high background activity due to spontaneous assembly. Here the authors present an automated approach which uses a split energy scoring function to identify optimal protein split sites and reduces spontaneous assembly.

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Autores principales:	Onur Dagliyan, Andrey Krokhotin, Irem Ozkan-Dagliyan, Alexander Deiters, Channing J. Der, Klaus M. Hahn, Nikolay V. Dokholyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9e3a56d1ffe4943ab95cf7844fce53d
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spelling	oai:doaj.org-article:a9e3a56d1ffe4943ab95cf7844fce53d2021-12-02T16:50:06ZComputational design of chemogenetic and optogenetic split proteins10.1038/s41467-018-06531-42041-1723https://doaj.org/article/a9e3a56d1ffe4943ab95cf7844fce53d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06531-4https://doaj.org/toc/2041-1723Designing split protein approaches is time consuming and often results in high background activity due to spontaneous assembly. Here the authors present an automated approach which uses a split energy scoring function to identify optimal protein split sites and reduces spontaneous assembly.Onur DagliyanAndrey KrokhotinIrem Ozkan-DagliyanAlexander DeitersChanning J. DerKlaus M. HahnNikolay V. DokholyanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Onur Dagliyan Andrey Krokhotin Irem Ozkan-Dagliyan Alexander Deiters Channing J. Der Klaus M. Hahn Nikolay V. Dokholyan Computational design of chemogenetic and optogenetic split proteins
description	Designing split protein approaches is time consuming and often results in high background activity due to spontaneous assembly. Here the authors present an automated approach which uses a split energy scoring function to identify optimal protein split sites and reduces spontaneous assembly.
format	article
author	Onur Dagliyan Andrey Krokhotin Irem Ozkan-Dagliyan Alexander Deiters Channing J. Der Klaus M. Hahn Nikolay V. Dokholyan
author_facet	Onur Dagliyan Andrey Krokhotin Irem Ozkan-Dagliyan Alexander Deiters Channing J. Der Klaus M. Hahn Nikolay V. Dokholyan
author_sort	Onur Dagliyan
title	Computational design of chemogenetic and optogenetic split proteins
title_short	Computational design of chemogenetic and optogenetic split proteins
title_full	Computational design of chemogenetic and optogenetic split proteins
title_fullStr	Computational design of chemogenetic and optogenetic split proteins
title_full_unstemmed	Computational design of chemogenetic and optogenetic split proteins
title_sort	computational design of chemogenetic and optogenetic split proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a9e3a56d1ffe4943ab95cf7844fce53d
work_keys_str_mv	AT onurdagliyan computationaldesignofchemogeneticandoptogeneticsplitproteins AT andreykrokhotin computationaldesignofchemogeneticandoptogeneticsplitproteins AT iremozkandagliyan computationaldesignofchemogeneticandoptogeneticsplitproteins AT alexanderdeiters computationaldesignofchemogeneticandoptogeneticsplitproteins AT channingjder computationaldesignofchemogeneticandoptogeneticsplitproteins AT klausmhahn computationaldesignofchemogeneticandoptogeneticsplitproteins AT nikolayvdokholyan computationaldesignofchemogeneticandoptogeneticsplitproteins
_version_	1718383118393540608

Computational design of chemogenetic and optogenetic split proteins

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