A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities...

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Autores principales:	Ositadinma Chinyere Ugbogu, Okezie Emmanuel, Grace Oka Agi, Chibuike Ibe, Celestine Nwabu Ekweogu, Victor Chibueze Ude, Miracle Ebubechi Uche, Rachel Oluchukwu Nnanna, Eziuche Amadike Ugbogu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Essential oil Ocimum gratissimum Pharmacological activities Phytochemicals Traditional uses Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/a9e5774f94f24e508982a770173bcecf
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spelling	oai:doaj.org-article:a9e5774f94f24e508982a770173bcecf2021-12-02T05:03:04ZA review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)2405-844010.1016/j.heliyon.2021.e08404https://doaj.org/article/a9e5774f94f24e508982a770173bcecf2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S240584402102507Xhttps://doaj.org/toc/2405-8440In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum. The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum, further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.Ositadinma Chinyere UgboguOkezie EmmanuelGrace Oka AgiChibuike IbeCelestine Nwabu EkweoguVictor Chibueze UdeMiracle Ebubechi UcheRachel Oluchukwu NnannaEziuche Amadike UgboguElsevierarticleEssential oilOcimum gratissimumPharmacological activitiesPhytochemicalsTraditional usesScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08404- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Essential oil Ocimum gratissimum Pharmacological activities Phytochemicals Traditional uses Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Essential oil Ocimum gratissimum Pharmacological activities Phytochemicals Traditional uses Science (General) Q1-390 Social sciences (General) H1-99 Ositadinma Chinyere Ugbogu Okezie Emmanuel Grace Oka Agi Chibuike Ibe Celestine Nwabu Ekweogu Victor Chibueze Ude Miracle Ebubechi Uche Rachel Oluchukwu Nnanna Eziuche Amadike Ugbogu A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
description	In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum. The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum, further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.
format	article
author	Ositadinma Chinyere Ugbogu Okezie Emmanuel Grace Oka Agi Chibuike Ibe Celestine Nwabu Ekweogu Victor Chibueze Ude Miracle Ebubechi Uche Rachel Oluchukwu Nnanna Eziuche Amadike Ugbogu
author_facet	Ositadinma Chinyere Ugbogu Okezie Emmanuel Grace Oka Agi Chibuike Ibe Celestine Nwabu Ekweogu Victor Chibueze Ude Miracle Ebubechi Uche Rachel Oluchukwu Nnanna Eziuche Amadike Ugbogu
author_sort	Ositadinma Chinyere Ugbogu
title	A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
title_short	A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
title_full	A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
title_fullStr	A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
title_full_unstemmed	A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
title_sort	review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (ocimum gratissimum l.)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a9e5774f94f24e508982a770173bcecf
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A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

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