Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

Yuqing Pan, Jun Yao, Baojie WangInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of ChinaAbstract: To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whethe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pan YQ, Yao J, Wang BJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a9e75353187b4a94b56892a32c422807
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a9e75353187b4a94b56892a32c422807
record_format	dspace
spelling	oai:doaj.org-article:a9e75353187b4a94b56892a32c4228072021-12-02T09:08:46ZAssociation of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis1178-2021https://doaj.org/article/a9e75353187b4a94b56892a32c4228072014-06-01T00:00:00Zhttp://www.dovepress.com/association-of-dopamine-d1-receptor-gene-polymorphism-with-schizophren-a17302https://doaj.org/toc/1178-2021 Yuqing Pan, Jun Yao, Baojie WangInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of ChinaAbstract: To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schizophrenia, using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria. A total of ten studies were identified and included in our meta-analysis, nine for rs4532, with 1,941 cases and 2,480 controls, and four for rs5326, with 1,285 cases and 1,195 controls. No significant association was found between the rs4532 locus and schizophrenia. For the rs5326 locus, the guanine-adenine (GA) genotype was associated with schizophrenia as a risk factor (for GA vs guanine-guanine [GG], odds ratio [OR] =1.36, 95% confidence interval [CI]: 1.15–1.61, P<0.001). The GA genotype of rs5326 increased the risk of schizophrenia, but there was no association between rs4532 and schizophrenia. These data may provide references for case-control studies in schizophrenia in future. Keywords: susceptibility, SNP, genetics, psychiatryPan YQYao JWang BJDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1133-1139 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pan YQ Yao J Wang BJ Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
description	Yuqing Pan, Jun Yao, Baojie WangInstitute of Forensic Medicine, China Medical University, Shenyang, People’s Republic of ChinaAbstract: To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schizophrenia, using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria. A total of ten studies were identified and included in our meta-analysis, nine for rs4532, with 1,941 cases and 2,480 controls, and four for rs5326, with 1,285 cases and 1,195 controls. No significant association was found between the rs4532 locus and schizophrenia. For the rs5326 locus, the guanine-adenine (GA) genotype was associated with schizophrenia as a risk factor (for GA vs guanine-guanine [GG], odds ratio [OR] =1.36, 95% confidence interval [CI]: 1.15–1.61, P<0.001). The GA genotype of rs5326 increased the risk of schizophrenia, but there was no association between rs4532 and schizophrenia. These data may provide references for case-control studies in schizophrenia in future. Keywords: susceptibility, SNP, genetics, psychiatry
format	article
author	Pan YQ Yao J Wang BJ
author_facet	Pan YQ Yao J Wang BJ
author_sort	Pan YQ
title	Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_short	Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_full	Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_fullStr	Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_full_unstemmed	Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_sort	association of dopamine d1 receptor gene polymorphism with schizophrenia: a meta-analysis
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a9e75353187b4a94b56892a32c422807
work_keys_str_mv	AT panyq associationofdopamined1receptorgenepolymorphismwithschizophreniaametaanalysis AT yaoj associationofdopamined1receptorgenepolymorphismwithschizophreniaametaanalysis AT wangbj associationofdopamined1receptorgenepolymorphismwithschizophreniaametaanalysis
_version_	1718398263784112128

Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

Ejemplares similares