Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol

Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization...

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Autores principales:	Denitsa Momekova, Yavor Danov, Georgi Momekov, Ervin Ivanov, Petar Petrov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cannabidiol cryogels β-cyclodextrin 2-hydroxyethyl cellulose drug delivery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/a9e9e859004c4a7ba842f2bb16ffdfa0
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spelling	oai:doaj.org-article:a9e9e859004c4a7ba842f2bb16ffdfa02021-11-25T18:40:35ZPolysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol10.3390/pharmaceutics131117741999-4923https://doaj.org/article/a9e9e859004c4a7ba842f2bb16ffdfa02021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1774https://doaj.org/toc/1999-4923Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization and therapeutic activity of CBD. Here, we report the preparation of original super-macroporous cryogels from 2-hydroxyethyl cellulose (HEC) and β-cyclodextrin (β-CD) designed for the topical delivery of CBD. The cryogels were synthesized by photochemical crosslinking in a frozen aqueous system, purified, and then loaded with CBD. The effect of HEC/β-CD mass ratio (100:0; 50:50; 40:60 and 20:80) in the reaction mixture on the reaction efficiency, physico-mechanical properties of cryogels, drug release profile, and antineoplastic potential were evaluated in detail. The cryogels showed a bi-phasic release behavior: initial burst release in the first 3 hours followed by slower drug release which can be beneficial in the treatment of cutaneous neoplastic diseases.Denitsa MomekovaYavor DanovGeorgi MomekovErvin IvanovPetar PetrovMDPI AGarticlecannabidiolcryogelsβ-cyclodextrin2-hydroxyethyl cellulosedrug deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1774, p 1774 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cannabidiol cryogels β-cyclodextrin 2-hydroxyethyl cellulose drug delivery Pharmacy and materia medica RS1-441
spellingShingle	cannabidiol cryogels β-cyclodextrin 2-hydroxyethyl cellulose drug delivery Pharmacy and materia medica RS1-441 Denitsa Momekova Yavor Danov Georgi Momekov Ervin Ivanov Petar Petrov Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
description	Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization and therapeutic activity of CBD. Here, we report the preparation of original super-macroporous cryogels from 2-hydroxyethyl cellulose (HEC) and β-cyclodextrin (β-CD) designed for the topical delivery of CBD. The cryogels were synthesized by photochemical crosslinking in a frozen aqueous system, purified, and then loaded with CBD. The effect of HEC/β-CD mass ratio (100:0; 50:50; 40:60 and 20:80) in the reaction mixture on the reaction efficiency, physico-mechanical properties of cryogels, drug release profile, and antineoplastic potential were evaluated in detail. The cryogels showed a bi-phasic release behavior: initial burst release in the first 3 hours followed by slower drug release which can be beneficial in the treatment of cutaneous neoplastic diseases.
format	article
author	Denitsa Momekova Yavor Danov Georgi Momekov Ervin Ivanov Petar Petrov
author_facet	Denitsa Momekova Yavor Danov Georgi Momekov Ervin Ivanov Petar Petrov
author_sort	Denitsa Momekova
title	Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_short	Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_full	Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_fullStr	Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_full_unstemmed	Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_sort	polysaccharide cryogels containing β-cyclodextrin for the delivery of cannabidiol
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a9e9e859004c4a7ba842f2bb16ffdfa0
work_keys_str_mv	AT denitsamomekova polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol AT yavordanov polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol AT georgimomekov polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol AT ervinivanov polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol AT petarpetrov polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol
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Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol

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