SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

Objective: Obesity-induced inflamed visceral adipose tissue (VAT) secretes pro-inflammatory cytokines thereby promoting systemic inflammation and insulin resistance which further exacerbate obesity-associated nonalcoholic fatty liver disease (NAFLD). Transforming growth factor (TGF)-β /Smad3 signali...

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Autores principales: Kisoo Pahk, Sang Gil Lee, Chanmin Joung, Eun-Ok Kim, Hyun Woo Kwon, Dong Hwi Kim, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
Obesity
NAFLD
TGF-β
Smad3
Inflammation
Visceral fat
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/a9ea870b08bb456f92e9402c01fb592c
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