The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis

Abstract Dietary palmitic acid (PA) promotes liver fibrosis in patients with nonalcoholic steatohepatitis (NASH). Herein, we clarified the intestinal absorption kinetics of dietary PA and effect of trans-portal PA on the activation of hepatic stellate cells (HSCs) involved in liver fibrosis in NASH....

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Autores principales:	Masakazu Hanayama, Yasunori Yamamoto, Hiroki Utsunomiya, Osamu Yoshida, Shuang Liu, Masaki Mogi, Bunzo Matsuura, Eiji Takeshita, Yoshiou Ikeda, Yoichi Hiasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9fe924bb8cb41818066b88cd7398b97
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spelling	oai:doaj.org-article:a9fe924bb8cb41818066b88cd7398b972021-12-02T16:10:35ZThe mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis10.1038/s41598-021-92790-z2045-2322https://doaj.org/article/a9fe924bb8cb41818066b88cd7398b972021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92790-zhttps://doaj.org/toc/2045-2322Abstract Dietary palmitic acid (PA) promotes liver fibrosis in patients with nonalcoholic steatohepatitis (NASH). Herein, we clarified the intestinal absorption kinetics of dietary PA and effect of trans-portal PA on the activation of hepatic stellate cells (HSCs) involved in liver fibrosis in NASH. Blood PA levels after meals were significantly increased in patients with NASH compared to those in the control. Expression of genes associated with fat absorption and chylomicron formation, such as CD36 and MTP, was significantly increased in the intestine of NASH model rats compared with that in the controls. Plasma levels of glucagon-like peptide-2, involved in the upregulation of CD36 expression, were elevated in NASH rats compared with those in the controls. Furthermore, portal PA levels after meals in NASH rats were significantly higher than those in control and nonalcoholic fatty liver rats. Moreover, PA injection into the portal vein to the liver in control rats increased the mRNA levels associated with the activation of HSCs. Increased intestinal absorption of diet-derived PA was observed in NASH. Thus, the rapid increase in PA levels via the portal vein to the liver may activate HSCs and affect the development of liver fibrosis in NASH.Masakazu HanayamaYasunori YamamotoHiroki UtsunomiyaOsamu YoshidaShuang LiuMasaki MogiBunzo MatsuuraEiji TakeshitaYoshiou IkedaYoichi HiasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masakazu Hanayama Yasunori Yamamoto Hiroki Utsunomiya Osamu Yoshida Shuang Liu Masaki Mogi Bunzo Matsuura Eiji Takeshita Yoshiou Ikeda Yoichi Hiasa The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
description	Abstract Dietary palmitic acid (PA) promotes liver fibrosis in patients with nonalcoholic steatohepatitis (NASH). Herein, we clarified the intestinal absorption kinetics of dietary PA and effect of trans-portal PA on the activation of hepatic stellate cells (HSCs) involved in liver fibrosis in NASH. Blood PA levels after meals were significantly increased in patients with NASH compared to those in the control. Expression of genes associated with fat absorption and chylomicron formation, such as CD36 and MTP, was significantly increased in the intestine of NASH model rats compared with that in the controls. Plasma levels of glucagon-like peptide-2, involved in the upregulation of CD36 expression, were elevated in NASH rats compared with those in the controls. Furthermore, portal PA levels after meals in NASH rats were significantly higher than those in control and nonalcoholic fatty liver rats. Moreover, PA injection into the portal vein to the liver in control rats increased the mRNA levels associated with the activation of HSCs. Increased intestinal absorption of diet-derived PA was observed in NASH. Thus, the rapid increase in PA levels via the portal vein to the liver may activate HSCs and affect the development of liver fibrosis in NASH.
format	article
author	Masakazu Hanayama Yasunori Yamamoto Hiroki Utsunomiya Osamu Yoshida Shuang Liu Masaki Mogi Bunzo Matsuura Eiji Takeshita Yoshiou Ikeda Yoichi Hiasa
author_facet	Masakazu Hanayama Yasunori Yamamoto Hiroki Utsunomiya Osamu Yoshida Shuang Liu Masaki Mogi Bunzo Matsuura Eiji Takeshita Yoshiou Ikeda Yoichi Hiasa
author_sort	Masakazu Hanayama
title	The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
title_short	The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
title_full	The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
title_fullStr	The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
title_full_unstemmed	The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
title_sort	mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a9fe924bb8cb41818066b88cd7398b97
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The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis

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