MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting glucose carbon to the TCA cycle and allowing p...

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Autores principales:	Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil, Mei Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9fee3fb145c4ef5be976c2f1bd995e7
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spelling	oai:doaj.org-article:a9fee3fb145c4ef5be976c2f1bd995e72021-12-02T17:01:27ZMiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-110.1038/s41467-019-08759-02041-1723https://doaj.org/article/a9fee3fb145c4ef5be976c2f1bd995e72019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08759-0https://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting glucose carbon to the TCA cycle and allowing pancreatic cancer cells survival.Ying YangMari B. Ishak GabraEric A. HanseXazmin H. LowmanThai Q. TranHaiqing LiNeta MilmanJuan LiuMichael A. ReidJason W. LocasaleZiv GilMei KongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Yang Mari B. Ishak Gabra Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Haiqing Li Neta Milman Juan Liu Michael A. Reid Jason W. Locasale Ziv Gil Mei Kong MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
description	Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting glucose carbon to the TCA cycle and allowing pancreatic cancer cells survival.
format	article
author	Ying Yang Mari B. Ishak Gabra Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Haiqing Li Neta Milman Juan Liu Michael A. Reid Jason W. Locasale Ziv Gil Mei Kong
author_facet	Ying Yang Mari B. Ishak Gabra Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Haiqing Li Neta Milman Juan Liu Michael A. Reid Jason W. Locasale Ziv Gil Mei Kong
author_sort	Ying Yang
title	MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
title_short	MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
title_full	MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
title_fullStr	MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
title_full_unstemmed	MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
title_sort	mir-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a9fee3fb145c4ef5be976c2f1bd995e7
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MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

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